Document Detail

Leptin response to carbohydrate or fat meal and association with subsequent satiety and energy intake.
MedLine Citation:
PMID:  10567012     Owner:  NLM     Status:  MEDLINE    
To assess the impact of the macronutrient content of a meal on the postprandial leptin response and its relationship with postprandial satiety, 22 young healthy subjects (11 men and 11 women) were given, in a randomized order, an isoenergetic meal [carbohydrate (81%) or fat (79%)] or remained fasting. Blood sampling and hunger and satiety scores were collected hourly during 9 h after the meal. Spontaneous intake was measured at a buffet meal at 9 h postprandially. In both genders, leptin response was higher after the carbohydrate meal than after the fat meal and while fasting. In women, leptin levels were higher after the fat meal than while fasting. Leptin response was significantly correlated to insulin response (r = 0.51, P < 0.0001). Hunger and satiety ratings and subsequent energy intake were not different after carbohydrate or fat intake. In conclusion, a carbohydrate meal induces higher postprandial leptin levels than an isoenergetic fat meal. Short-term regulation of postprandial satiety and food intake is not influenced by circulating leptin.
M Romon; P Lebel; C Velly; N Marecaux; J C Fruchart; J Dallongeville
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E855-61     Citation Subset:  IM    
Service de Nutrition, Centre Hospitalier Universitaire, 59000 Lille, France.
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MeSH Terms
Dietary Carbohydrates / administration & dosage*
Dietary Fats / administration & dosage*
Eating / physiology
Energy Metabolism / physiology*
Hunger / physiology
Leptin / blood*
Postprandial Period
Satiation / physiology*
Reg. No./Substance:
0/Dietary Carbohydrates; 0/Dietary Fats; 0/Leptin

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