Document Detail


Leptin and resistin levels and their relationships with glucose metabolism in children with chronic renal insufficiency and undergoing dialysis.
MedLine Citation:
PMID:  16756630     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: The aim of the present study is: (i) to evaluate the serum concentrations of leptin and resistin in the paediatric patients with chronic renal impairment (CRI), on haemodialysis (HD) and on peritoneal dialysis (PD) treatment; (ii) to examine the relationship between these hormones; and (iii) to investigate the possible influence of these hormones on the insulin resistance and sensitivity indexes as well as on serum insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) levels. METHODS: In total, 52 patients (15 patients with CRI, 24 PD patients and 13 HD patients) and 23 healthy age- and sex-matched control subjects were included in the present study. RESULTS: Homeostasis model assessment of insulin resistance (HOMA-IR) was higher than 2.5 in 47.1% of the patients. IGF-1 levels of patients with CRI, PD and HD patients were significantly lower than those in the controls (P < 0.001, P < 0.001, P < 0.001, respectively). The leptin levels of patients with CRI and on PD and HD treatment were significantly higher than the control group (P = 0.038, P = 0.002, P = 0.006, respectively). Similarly, serum resistin levels of patients with CRI and those of PD and HD patients were higher when compared with healthy controls (P = 0.037, P < 0.001, P = 0.005, respectively). CONCLUSION: Leptin and resistin levels were increased in the children with CRF; however, this elevation was not found to be associated with hyperinsulinism. Further studies to explain the mechanisms and consequences of the accumulation of these hormones in CRF may provide the therapeutical approach aiming to normalize their circulating levels.
Authors:
Necla Buyan; Buyan Necla; Aysun Bideci; Bideci Aysun; Ozan Ozkaya; Ozkaya Ozan; Erol Ortac; Ortac Erol; Sevcan Bakkaloglu; Bakkaloglu Sevcan; Sevim Gonen; Gonen Sevim; Harun Peru; Peru Harun; Oğuz Soylemezoglu; Soylemezoglu Oğuz; Peyami Cinaz; Cinaz Peyami
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nephrology (Carlton, Vic.)     Volume:  11     ISSN:  1320-5358     ISO Abbreviation:  Nephrology (Carlton)     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-07     Completed Date:  2006-10-20     Revised Date:  2006-12-28    
Medline Journal Info:
Nlm Unique ID:  9615568     Medline TA:  Nephrology (Carlton)     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  192-6     Citation Subset:  IM    
Affiliation:
Department of Pediatric Nephrology, Gazi University, Ankara, Turkey. nbuyan@gazi.edu.tr
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Child
Child, Preschool
Female
Glucose / metabolism*
Humans
Leptin / blood*
Male
Renal Dialysis*
Renal Insufficiency, Chronic / blood*,  therapy*
Resistin / blood*
Chemical
Reg. No./Substance:
0/Leptin; 0/Resistin; 50-99-7/Glucose
Comments/Corrections
Erratum In:
Nephrology (Carlton). 2006 Dec;11(6):570
Note: Necla, Buyan [corrected to Buyan, Necla]; Aysun, Bideci [corrected to Bideci, Aysun]; Ozan, Ozkaya [corrected to Ozkaya, Ozan]; Erol, Ortac [corrected to Ortac, Erol]; Sevcan, Bakkaloglu [corrected to Bakkaloglu, Sevcan]; Sevim, Gonen [corrected to Gonen, Sevim]; Harun, Peru [corrected to Peru, Harun]; Oguz, Soylemezoglu [corrected to Soylemezoglu, Oguz]; Peyami, Cinaz [corrected to Cinaz, Peyami]

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