Document Detail

Leptin requirement for conception, implantation, and gestation in the mouse.
MedLine Citation:
PMID:  11713215     Owner:  NLM     Status:  MEDLINE    
The ob/ob mouse has a complete absence of circulating leptin, resulting in obesity and infertility. Using the minimum daily dose of leptin required to maintain normal body weight and sexual maturation (5 mg/kg, ip), leptin-treated ob/ob females were mated with either wild-type (+/+) or leptin-treated ob/ob males. The leptin treatment continued throughout pregnancy until weaning or was withdrawn at 0.5, 3.5, 6.5, or 14.5 d post coitum (dpc). Normal pregnancy and parturition with pups of normal weight resulted when ob/ob females were mated with +/+ males and leptin treatment was continued throughout pregnancy (6 of 8 pregnancies), to 14.5 dpc (6 of 8 pregnancies), or to 6.5 dpc (9 of 12 pregnancies). Pregnancy did not result when treatment was stopped at 3.5 dpc (1 of 7 pregnancies) or 0.5 dpc (0 of 6 pregnancies). Similar results were obtained when leptin-treated ob/ob females were mated with leptin-treated ob/ob males. The newborn pups failed to survive after birth in groups treated with leptin up to 14.5 and 6.5 dpc despite reinstating leptin at birth. This appeared to be due to a lack of development of the mammary glands. In conclusion, we have shown that leptin is essential for normal preimplantation and/or implantation processes. It is also essential for normal development of the mammary glands, but is not required for pregnancy and parturition once implantation is established.
N M Malik; N D Carter; J F Murray; R J Scaramuzzi; C A Wilson; M J Stock
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Endocrinology     Volume:  142     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-11-19     Completed Date:  2001-12-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5198-202     Citation Subset:  AIM; IM    
Department of Physiology, St. Georges Hospital Medical School, London, United Kingdom SW17 0RE.
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MeSH Terms
Embryo Implantation / drug effects,  physiology*
Fertilization / drug effects,  physiology*
Leptin / pharmacology,  physiology*
Mammary Glands, Animal / drug effects,  growth & development
Obesity / genetics,  physiopathology
Pregnancy, Animal / drug effects,  physiology*
Time Factors
Reg. No./Substance:

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