Document Detail

Leptin and reproduction: is it a critical link between adipose tissue, nutrition, and reproduction?
MedLine Citation:
PMID:  10470449     Owner:  NLM     Status:  MEDLINE    
Exercise-associated reproductive disorders are frequently reported among recreationally active and elite female athletes. Although an association between exercise and menstrual disorders has been established, the mechanism by which exercise disrupts reproductive function remains unknown. Recent findings suggest that low energy availability rather than inadequate body fatness or exercise stress is likely the mechanism by which exercise impinges negatively on the hypothalamic-pituitary-ovarian axis in female athletes. The peripheral signal that informs the neural network of energy availability remains unknown. The identification of the adipocyte-derived ob gene product, leptin, and subsequent findings of its association with reproduction in both rodents and humans, led to speculations that it may be involved in the interactions between nutrition and reproduction. This review article focuses on leptin's role in modulating reproduction, and in particular, as a peripheral signal of nutritional status that integrates adipose tissue, nutrition, and reproduction in female athletes.
F S Thong; T E Graham
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  24     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-19     Completed Date:  1999-10-19     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  317-36     Citation Subset:  IM    
Department of Human Biology and Nutritional Sciences, University of Guelph, Ontario.
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MeSH Terms
Adipose Tissue / metabolism,  physiology
Energy Metabolism / physiology
Exercise / physiology*
Hormones / physiology
Menstrual Cycle / physiology
Menstruation Disturbances / etiology,  physiopathology*
Nutritional Physiological Phenomena
Proteins / metabolism,  physiology*
Reproduction / physiology*
Reg. No./Substance:
0/Hormones; 0/Leptin; 0/Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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