Document Detail


Leptin replacement alters brain response to food cues in genetically leptin-deficient adults.
MedLine Citation:
PMID:  17986612     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A missense mutation in the ob gene causes leptin deficiency and morbid obesity. Leptin replacement to three adults with this mutation normalized body weight and eating behavior. Because the neural circuits mediating these changes were unknown, we paired functional magnetic resonance imaging (fMRI) with presentation of food cues to these subjects. During viewing of food-related stimuli, leptin replacement reduced brain activation in regions linked to hunger (insula, parietal and temporal cortex) while enhancing activation in regions linked to inhibition and satiety (prefrontal cortex). Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity.
Authors:
Kate Baicy; Edythe D London; John Monterosso; Ma-Li Wong; Tuncay Delibasi; Anil Sharma; Julio Licinio
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2007-11-06
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  104     ISSN:  1091-6490     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-11-16     Completed Date:  2008-01-10     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  18276-9     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA.
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MeSH Terms
Descriptor/Qualifier:
Brain / drug effects*,  physiology
Feeding Behavior / drug effects*
Humans
Leptin / administration & dosage,  pharmacology*
Magnetic Resonance Imaging
Grant Support
ID/Acronym/Agency:
DA020726/DA/NIDA NIH HHS; DA021961/DA/NIDA NIH HHS; DA022539/DA/NIDA NIH HHS; DK058851/DK/NIDDK NIH HHS; DK063240/DK/NIDDK NIH HHS; GM061394/GM/NIGMS NIH HHS; GM08042/GM/NIGMS NIH HHS; RR00865/RR/NCRR NIH HHS; RR016996/RR/NCRR NIH HHS; RR017365/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Leptin
Comments/Corrections

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