| Leptin is related to body fat content in male distance runners. | |
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MedLine Citation:
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PMID: 8944684 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin, the product of the ob gene, has been reported to be related to body fat in humans (Considine et al. N. Engl. J. Med. 334: 292, 1996). However, little is known about the physiology of this putative satiety signal in humans. The purpose of the present study was to determine whether leptin is related to body fat content in relatively lean endurance-trained adults. In addition, the effect of acute exercise on circulating leptin concentration was studied. Thirteen male runners, whose mean age, height, weight, %fat, and maximal oxygen consumption (VO2max) were 32.2 +/- 2.5 yr, 176.2 +/- 1.6 cm, 71.9 +/- 6.9 kg, 9.7 +/- 0.9%, and 62.9 +/- 2.2 ml.kg-1.min-1, respectively, were studied. Blood samples were obtained after an overnight fast and again immediately after the completion of a 20-mile run at 70% VO2max under controlled environmental conditions. Serum leptin was closely related to fat mass (r = 0.92) in the runners. Acute exercise had no detectable effect on serum leptin levels (PRE = 2.19 +/- 0.32 ng/ml, POST = 2.14 +/- 0.36 ng/ml). These data indicate that, even at a biological extreme of body fat, circulating leptin concentration is closely related to fat content. Furthermore, the data suggest that, in trained individuals with low leptin concentrations, acute exhaustive exercise has no immediate effect on circulating leptin concentration. |
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Authors:
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M S Hickey; R V Considine; R G Israel; T L Mahar; M R McCammon; G L Tyndall; J A Houmard; J F Caro |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 271 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1996 Nov |
Date Detail:
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Created Date: 1997-01-09 Completed Date: 1997-01-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: E938-40 Citation Subset: IM |
Affiliation:
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Department of Exercise and Sport Science, School of Health and Human Performance, East Carolina University Greenville, North Carolina 27858, USA. HPHickey@ECUVM.CIS.ECU.EDU |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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anatomy & histology*,
physiology Adult Body Mass Index Exercise Test Fasting Humans Leptin Male Middle Aged Obesity Oxygen Consumption Physical Exertion Proteins / analysis, metabolism* Running* |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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