Document Detail


Leptin regulation of lipid homeostasis: dietary and metabolic implications.
MedLine Citation:
PMID:  19079939     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Leptin is a 16 kDa protein synthesized and secreted primarily from adipocytes. Leptin acts centrally to regulate appetite and energy expenditure and has peripheral effects to coordinate whole-body energy metabolism. Leptin acts as an energy balance and nutrient sensor; its expression and function are regulated by endocrine and dietary factors. Leptin regulates lipid metabolism, specifically lipid storage in adipocytes as well as in skeletal muscle, liver and the pancreas. Effects of leptin on tissue lipid metabolism include regulation of lipogenesis and fatty acid oxidation. Leptin resistance is a hallmark of rodent and human obesity and appears to be due to defects in leptin-receptor signalling (proximal and perhaps distal) as well as impaired leptin transport into the brain. Dietary composition, especially dietary fatty acid intake and profile, impacts on the expression of genes encoding leptin and leptin receptors as well as downstream leptin effectors. Dietary fat consumption, especially consumption of saturated fatty acids, can induce leptin resistance. Leptin has been implicated in nutritional programming during fetal and neonatal growth with long-term effects on susceptibility to obesity, diabetes and CHD in adults.
Authors:
Karen L Houseknecht; Michael E Spurlock
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nutrition research reviews     Volume:  16     ISSN:  1475-2700     ISO Abbreviation:  Nutr Res Rev     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2008-12-16     Completed Date:  2009-12-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9113797     Medline TA:  Nutr Res Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  83-96     Citation Subset:  -    
Affiliation:
Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, MS 8220-3071, Eastern Point Road, Groton, CT 06340, USA. Karen_L_Houseknecht@groton.pfizer.com
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