Document Detail

Leptin regulates striatal regions and human eating behavior.
MedLine Citation:
PMID:  17690262     Owner:  NLM     Status:  MEDLINE    
Studies of the fat-derived hormone leptin have provided key insights into the molecular and neural components of feeding behavior and body weight regulation. An important challenge lies in understanding how the rewarding properties of food interact with, and can override, physiological satiety signals and promote overeating. We used functional magnetic resonance imaging to measure brain responses in two human patients with congenital leptin deficiency who were shown images of food before and after 7 days of leptin replacement therapy. Leptin was found to modulate neural activation in key striatal regions, suggesting that the hormone acts on neural circuits governing food intake to diminish the perception of food reward while enhancing the response to satiety signals generated during food consumption.
I Sadaf Farooqi; Edward Bullmore; Julia Keogh; Jonathan Gillard; Stephen O'Rahilly; Paul C Fletcher
Publication Detail:
Type:  Case Reports; Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-08-09
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  317     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-07     Completed Date:  2007-09-21     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355     Citation Subset:  IM    
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MeSH Terms
Brain Mapping
Corpus Striatum / drug effects,  physiology*
Feeding Behavior / drug effects,  physiology*
Leptin / deficiency*,  physiology*,  therapeutic use
Magnetic Resonance Imaging
Nucleus Accumbens / physiology
Satiation / physiology
Visual Perception / drug effects,  physiology
Grant Support
064351//Wellcome Trust; 068086//Wellcome Trust; G0001354//Medical Research Council; G9824984//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
Comment In:
Cell Metab. 2007 Dec;6(6):423-5   [PMID:  18054310 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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