|Leptin regulates the reward value of nutrient.|
|PMID: 22081158 Owner: NLM Status: MEDLINE|
|We developed an assay for quantifying the reward value of nutrient and used it to analyze the effects of metabolic state and leptin. In this assay, mice chose between two sippers, one of which dispensed water and was coupled to optogenetic activation of dopaminergic (DA) neurons and the other of which dispensed natural or artificial sweeteners. This assay measured the reward value of sweeteners relative to lick-induced optogenetic activation of DA neurons. Mice preferred optogenetic stimulation of DA neurons to sucralose, but not to sucrose. However, the mice preferred sucralose plus optogenetic stimulation versus sucrose. We found that food restriction increased the value of sucrose relative to sucralose plus optogenetic stimulation, and that leptin decreased it. Our data suggest that leptin suppresses the ability of sucrose to drive taste-independent DA neuronal activation and provide new insights into the mechanism of leptin's effects on food intake.|
|Ana I Domingos; Jake Vaynshteyn; Henning U Voss; Xueying Ren; Viviana Gradinaru; Feng Zang; Karl Deisseroth; Ivan E de Araujo; Jeffrey Friedman|
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|Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-11-13|
|Title: Nature neuroscience Volume: 14 ISSN: 1546-1726 ISO Abbreviation: Nat. Neurosci. Publication Date: 2011 Dec|
|Created Date: 2011-11-28 Completed Date: 2012-01-20 Revised Date: 2014-11-09|
Medline Journal Info:
|Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States|
|Languages: eng Pagination: 1562-8 Citation Subset: IM|
|APA/MLA Format Download EndNote Download BibTex|
Analysis of Variance
Choice Behavior / drug effects, physiology
Dopamine Plasma Membrane Transport Proteins / genetics
Dose-Response Relationship, Drug
Drinking Behavior / drug effects
Fasting / metabolism
Food Preferences / drug effects*
Gene Expression Regulation / drug effects
Image Processing, Computer-Assisted
Leptin / metabolism, pharmacology*
Luminescent Proteins / genetics
Magnetic Resonance Imaging
Mice, Inbred C57BL
Neurons / drug effects, physiology, radiation effects
Oxygen / blood
Proteins / genetics
Proto-Oncogene Proteins c-fos / metabolism
Rhodopsin / genetics
Sucrose / administration & dosage, analogs & derivatives
Sweetening Agents / administration & dosage
Tyrosine 3-Monooxygenase / metabolism
Ventral Tegmental Area / blood supply, cytology, metabolism, radiation effects
|DC009997/DC/NIDCD NIH HHS; MH075957/MH/NIMH NIH HHS; R01 MH075957/MH/NIMH NIH HHS|
|0/Dopamine Plasma Membrane Transport Proteins; 0/Gt(ROSA)26Sor non-coding RNA, mouse; 0/Leptin; 0/Luminescent Proteins; 0/Proteins; 0/Proto-Oncogene Proteins c-fos; 0/RNA, Untranslated; 0/Sweetening Agents; 0/channelrhodopsin 2, mouse; 56038-13-2/trichlorosucrose; 57-50-1/Sucrose; 9009-81-8/Rhodopsin; EC 184.108.40.206/Tyrosine 3-Monooxygenase; S88TT14065/Oxygen|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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