| Leptin potentiates the anti-obesity effects of rimonabant. | |
| | |
MedLine Citation:
|
PMID: 21371466 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
We hypothesized that a combination of low doses of rimonabant and leptin would markedly reduce body weight through modulation of neuronal activity within the hypothalamus. To this end, high fat diet-induced obese rats were randomized to receive either leptin (0.5mg/kg subcutaneously), rimonabant (3mg/kg), the combination of both, or vehicle, daily for a duration of 2weeks. A subset of rats was pair-fed to the combination-treated animals and received either vehicle or leptin. At the end of the weight loss phase, leptin treatment was maintained for 7days while rimonabant was discontinued to assess changes in body weight during the rebound phase. The combination of rimonabant and leptin resulted in a marked inhibition of food intake and a profound reduction in body weight that was greater than achieved with either leptin or rimonabant alone. Treatment with leptin during the rebound phase inhibited compensatory increases in body weight associated with restitution of ad libitum feeding in previously pair-fed rats. Moreover, leptin partially blunted the rebound in food intake and body weight associated with cessation of rimonabant therapy. To investigate the effect of the combination on neuronal firing in the rat hypothalamus, single unit activity was recorded from brain slices containing the ventromedial and arcuate nuclei. The combination of rimonabant and leptin synergistically increased and decreased neuronal firing in the ventromedial and arcuate nuclei, respectively. Overall, these data demonstrate profound anti-obesity effects of combining cannabinoid type 1 receptor antagonists and leptin. |
| | |
Authors:
|
Carine M Boustany-Kari; V Margaret Jackson; Colleen P Gibbons; Andrew G Swick |
Related Documents
:
|
8745886 - Periodicity in the growth and shedding of hair. 7369156 - Effects of zinc intake on copper balance in adult females. 4383136 - Daily rhythm in tyrosine concentration in human plasma: persistence on low-protein diets. 6687606 - Plasma levels of prostaglandin metabolites in zinc-deficient female rats near term. 2689416 - Effects of recombinant dna-derived somatotropin and dietary energy intake on developmen... 20437476 - Effect of maternal diet rich in omega-6 and omega-9 fatty acids on the liver of ldl rec... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-28 |
Journal Detail:
|
Title: European journal of pharmacology Volume: - ISSN: 1879-0712 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2010. Published by Elsevier B.V. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Antioxidant and signal modulation properties of plant polyphenols in controlling vascular inflammati...
Next Document: Effects of des-aspartate-angiotensin I on myocardial ischemia-reperfusion injury in rats.