Document Detail


Leptin and post-prandial satiety: acute central leptin more potently reduces meal frequency than meal size in the rat.
MedLine Citation:
PMID:  15609069     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Many attempts to understand ingestion have sought to clarify the control of meals. Little is known about the effects of the anorexogenic hormone leptin on meal patterning. OBJECTIVE: The present study sought to perform a dose-response analysis of the effects of acute central leptin administration on meal patterning using a validated, objective meal definition and to compare these results to those obtained with a previously used, subjective meal definition. METHODS: To validate the objective meal definition pharmacologically, the microstructural effects of the well-studied compound fenfluramine (SC 0, 1, 2, 4 mg/kg) on spontaneous nocturnal intake were determined in mature, non-deprived male Wistar rats (n=8) using a full Latin square design. The effects of intracerebroventricular leptin administration (0, 0.3, 1, 3, 6.25 microg; n=10) were also examined, and perceived meal patterns obtained from the objective and subjective definitions were compared. RESULTS: Fenfluramine reduced meal size and eating rate at doses that did not reduce meal frequency or duration. In contrast, comparably anorectic doses of leptin had potent post-meal satiety-like effects, reducing meal frequency and prolonging the intermeal interval without reducing average meal size, a finding opposite to that suggested by the previously used subjective meal definition. Unlike comparably and more anorectic doses of fenfluramine, leptin non-specifically reduced both prandial and non-prandial drinking. CONCLUSIONS: Acute increases in central leptin levels may potently augment post-prandial satiety and influence body-fluid homeostasis. The results reveal unappreciated central modes of action for the ob protein which qualitatively differ from the intra-meal satiating-like effects of fenfluramine.
Authors:
Eric P Zorrilla; Koki Inoue; Glenn R Valdez; Antoine Tabarin; George F Koob
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2004-07-27
Journal Detail:
Title:  Psychopharmacology     Volume:  177     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2004-12-20     Completed Date:  2005-09-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  324-35     Citation Subset:  IM    
Affiliation:
Department of Neuropharmacology, The Scripps Research Institute, 10550 N.Torrey Pines Rd., La Jolla, CA 92037, USA. ezorrilla@scripps.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / drug effects*,  physiology
Circadian Rhythm / drug effects,  physiology
Dose-Response Relationship, Drug
Drinking / drug effects,  physiology
Eating / drug effects,  physiology
Fenfluramine / administration & dosage,  pharmacokinetics
Injections, Intraventricular
Injections, Subcutaneous
Leptin / administration & dosage,  metabolism,  pharmacokinetics*
Male
Postprandial Period / drug effects*,  physiology
Psychopharmacology / methods
Rats
Rats, Wistar
Satiety Response / drug effects*,  physiology
Grant Support
ID/Acronym/Agency:
AA05563/AA/NIAAA NIH HHS; DK26741/DK/NIDDK NIH HHS; DK64871/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Leptin; 458-24-2/Fenfluramine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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