Document Detail


Leptin and ovarian folliculogenesis: implications for ovulation induction and ART outcomes.
MedLine Citation:
PMID:  12087495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin participates in regulation of ovarian folliculogenesis indirectly via control of luteinizing hormone and follicle-stimulating hormone secretion. More recent evidence suggests that leptin also has direct regulatory actions on the developing follicle. The presence of leptin receptors on follicular cells, including oocytes, and early preimplantation embryos suggests that leptin may play a direct physiologic role in follicular maturation, oocyte development, and early cleavage. Because circulating leptin levels are directly related to body adiposity, elevated leptin concentrations associated with obesity may partly explain the negative impact of obesity on fertility. The influence of leptin on follicular development and oocyte maturation has important implications for ovulation induction and assisted reproductive technologies. Moreover, polycystic ovarian syndrome may be associated with altered leptin phsyiology.
Authors:
John D Brannian; Keith A Hansen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  20     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-11-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-12     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, University of South Dakota School of Medicine, Sioux Falls, South Dakota 57105-1570, USA.
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MeSH Terms
Descriptor/Qualifier:
Female
Gonadotropins / administration & dosage
Humans
Leptin / physiology*,  secretion
Menstrual Cycle
Ovarian Follicle / physiology*
Ovary / drug effects
Ovulation Induction*
Polycystic Ovary Syndrome
Reproductive Techniques, Assisted*
Treatment Outcome*
Grant Support
ID/Acronym/Agency:
HD35333/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Gonadotropins; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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