Document Detail

Leptin and neuropeptide y have opposing modulatory effects on nucleus of the solitary tract neurophysiological responses to gastric loads: implications for the control of food intake.
MedLine Citation:
PMID:  12239088     Owner:  NLM     Status:  MEDLINE    
Leptin is an adiposity hormone that modulates the activity of multiple hypothalamic signaling pathways involved in the control of food intake. The present experiments were designed to evaluate whether central administration of leptin or one of its downstream mediators, neuropeptide Y (NPY), could affect food intake by modulating the brain stem neurophysiological response to ascending meal-related feedback signals in the nucleus of the solitary tract (NTS) in anesthetized male Long-Evans rats. NTS neurons at the rostrocaudal level of the area postrema were dose-dependently activated by gastric loads ranging from 2-10 ml, and leptin and NPY had opposite modulatory effects on this load volume/activity relationship: leptin significantly increased NTS responses to gastric loads, whereas NPY reduced the potency and efficacy with which gastric loads activated NTS neurons. These effects were probably not mediated by peripheral effects of centrally administered peptides or by the gastrokinetic effects of central NPY or leptin, because the dose-response relationship between gastric load volume and neurophysiological firing rate was unchanged in gastric load-sensitive vagal afferent fibers. These data suggest a mechanistic framework for considering how feeding behavior occurring in meals is altered by challenges to energy homeostasis, such as fasting and overfeeding.
Gary J Schwartz; Timothy H Moran
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Endocrinology     Volume:  143     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-19     Completed Date:  2002-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3779-84     Citation Subset:  AIM; IM    
Bourne Behavioral Research Laboratory, Department of Psychiatry, WMC Cornell University, White Plains, New York 10605, USA.
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MeSH Terms
Eating / physiology*
Injections, Intraventricular
Leptin / administration & dosage,  pharmacology*
Neuropeptide Y / administration & dosage,  pharmacology*
Rats, Long-Evans
Solitary Nucleus / drug effects*,  physiology*
Third Ventricle
Grant Support
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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