Document Detail


Leptin levels in restricting and purging anorectics.
MedLine Citation:
PMID:  10422608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with anorexia nervosa of the restricting (AN-R) and purging (AN-P) subtypes were studied to determine if there was a differential effect on leptin levels. It was hypothesized that the AN-P subgroup would have elevated leptin compared to the AN-R subgroup. Fasting plasma and anthropormorphic measurements were collected from 8 women with AN-R and 5 with AN-P. Eleven women served as controls. Overall, the plasma leptin correlated with body mass index (BMI; R = 0.432, p < .05). The AN-P subgroup had elevated leptin compared to the AN-R subgroup (3.8 +/- 0.8 vs. 1.5 +/- 0.2 ng/ml, p < .05) despite similar BMI (16.0 +/- 0.5 vs. 14.8 +/- 0.8 kg/m2). Additionally, the AN-P subgroup had similar plasma leptins as controls (3.8 +/- 0.8 vs. 3.6 +/- 0.1) despite different BMI (16.0 +/- 0.5 vs. 20.2 +/- 0.2, p < .001). Cortisol in the AN-P subgroup trended to be higher than in the restricting anorectics (21.8 +/- 3.0 vs. 15.6 +/- 1.3, p = .06). In AN, leptin was elevated in AN-P vs. AN. This may be due to increased glucocorticoid stimulation of leptin.
Authors:
P S Mehler; R H Eckel; W T Donahoo
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The International journal of eating disorders     Volume:  26     ISSN:  0276-3478     ISO Abbreviation:  Int J Eat Disord     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-29     Completed Date:  1999-10-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8111226     Medline TA:  Int J Eat Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-94     Citation Subset:  IM    
Affiliation:
Division of General Internal Medicine, Denver Health Medical Center, Colorado 80204, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anorexia Nervosa / blood*
Anthropometry
Blood Proteins / analysis*
Body Mass Index
Bulimia / blood*
Female
Humans
Hydrocortisone / blood
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Blood Proteins; 50-23-7/Hydrocortisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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