| Leptin levels in restricting and purging anorectics. | |
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MedLine Citation:
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PMID: 10422608 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Patients with anorexia nervosa of the restricting (AN-R) and purging (AN-P) subtypes were studied to determine if there was a differential effect on leptin levels. It was hypothesized that the AN-P subgroup would have elevated leptin compared to the AN-R subgroup. Fasting plasma and anthropormorphic measurements were collected from 8 women with AN-R and 5 with AN-P. Eleven women served as controls. Overall, the plasma leptin correlated with body mass index (BMI; R = 0.432, p < .05). The AN-P subgroup had elevated leptin compared to the AN-R subgroup (3.8 +/- 0.8 vs. 1.5 +/- 0.2 ng/ml, p < .05) despite similar BMI (16.0 +/- 0.5 vs. 14.8 +/- 0.8 kg/m2). Additionally, the AN-P subgroup had similar plasma leptins as controls (3.8 +/- 0.8 vs. 3.6 +/- 0.1) despite different BMI (16.0 +/- 0.5 vs. 20.2 +/- 0.2, p < .001). Cortisol in the AN-P subgroup trended to be higher than in the restricting anorectics (21.8 +/- 3.0 vs. 15.6 +/- 1.3, p = .06). In AN, leptin was elevated in AN-P vs. AN. This may be due to increased glucocorticoid stimulation of leptin. |
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Authors:
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P S Mehler; R H Eckel; W T Donahoo |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: The International journal of eating disorders Volume: 26 ISSN: 0276-3478 ISO Abbreviation: Int J Eat Disord Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-29 Completed Date: 1999-10-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8111226 Medline TA: Int J Eat Disord Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 189-94 Citation Subset: IM |
Affiliation:
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Division of General Internal Medicine, Denver Health Medical Center, Colorado 80204, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anorexia Nervosa / blood* Anthropometry Blood Proteins / analysis* Body Mass Index Bulimia / blood* Female Humans Hydrocortisone / blood Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 50-23-7/Hydrocortisone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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