Document Detail

Leptin levels in the differential diagnosis between benign and malignant ascites.
MedLine Citation:
PMID:  17230608     Owner:  NLM     Status:  MEDLINE    
AIM: To evaluate the role of leptin levels in the differential diagnosis of ascites.
METHODS: Ascitic leptin, TNFalpha and serum leptin levels were measured in 77 patients with ascites (35 with malignancies, 30 cirrhosis and 12 tuberculosis). Control serum samples were obtained from 20 healthy subjects. Leptin and TNFalpha levels were measured by ELISA. Body mass index (BMI) and percentage of body fat (BFM) by skin fold measurement were calculated for all patients and control groups. Peritoneal biopsy, ascites cytology and cultures or biochemical values were used for the diagnosis of patients.
RESULTS: In patients with malignancies, the mean serum and ascites leptin levels and their ratios were significantly decreased compared to the other patient groups and controls. In tuberculosis peritonitis, ascitic fluid TNFalpha levels were significantly higher than malignant ascites and cirrhotic sterile ascites. BMI and BFM values did not distinguish between patients and controls.
CONCLUSION: In patients with malignant ascites, levels of leptin and TNFalpha were significantly lower than in patients with tuberculous ascites.
Mehmet Buyukberber; Mehmet Koruk; M-Cemil Savas; Murat-T Gulsen; Yavuz Pehlivan; Rukiye Deveci; Alper Sevinc; Serdar Gergerlioglu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-18     Completed Date:  2007-03-22     Revised Date:  2014-09-07    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  398-402     Citation Subset:  IM    
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MeSH Terms
Ascites / diagnosis*,  metabolism
Diagnosis, Differential
Leptin / blood,  metabolism*
Middle Aged
Prospective Studies
Tumor Necrosis Factor-alpha / metabolism
Reg. No./Substance:
0/Leptin; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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