| Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. | |
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MedLine Citation:
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PMID: 21281328 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Karakosta P, Chatzi L, Plana E, Margioris A, Castanas E, Kogevinas M. Leptin levels in cord blood and anthropometric measures at birth: a systematic review and meta-analysis. Paediatric and Perinatal Epidemiology 2010. The role of intrauterine environment in the development of obesity is increasingly recognised. Adipokines and specifically leptin have been examined as potential biomarkers predicting early development of obesity. We conducted a systematic review and meta-analysis of the epidemiological evidence for the association between leptin levels in cord blood and anthropometric measurements at birth in healthy mother-newborn pairs. A PubMed search was performed between 1994 and 2009 and manual search of reference lists of retrieved articles. Forty-four studies met the inclusion criteria set. All studies reported a positive correlation between leptin levels and birthweight. The combined correlation coefficient (r) was 0.46 [95%CI 0.43, 0.50]. Leptin levels explained 21% of variation in birthweight. Results were similar in males (r = 0.55; 0.40, 0.68) and females (r = 0.60; 0.50, 0.69), and between Caucasians (r = 0.45; 0.39, 0.51) and eastern Asian populations (r = 0.47; 0.37, 0.55). Statistically significant positive correlations were also found for birth length (r = 0.29; 0.23, 0.34) and ponderal index (r = 0.36; 0.31, 0.41). There was no indication of publication bias (Egger's test P-value = 0.23). This meta-analysis shows a clear but moderate correlation between leptin levels in cord blood and birthweight that is observed in different population groups. |
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Authors:
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Polyxeni Karakosta; Leda Chatzi; Estel Plana; Andrew Margioris; Elias Castanas; Manolis Kogevinas |
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Publication Detail:
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Type: Journal Article Date: 2010-12-09 |
Journal Detail:
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Title: Paediatric and perinatal epidemiology Volume: 25 ISSN: 1365-3016 ISO Abbreviation: Paediatr Perinat Epidemiol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-01 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8709766 Medline TA: Paediatr Perinat Epidemiol Country: England |
Other Details:
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Languages: eng Pagination: 150-63 Citation Subset: IM |
Copyright Information:
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© 2010 Blackwell Publishing Ltd. |
Affiliation:
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Departments of Social Medicine Clinical Chemistry-Biochemistry Experimental Endocrinology, Faculty of Medicine, University of Crete, Heraklion National School of Public Health, Athens, Greece Centre for Research in Environmental Epidemiology (CREAL) Municipal Institute of Medical Research (IMIM) CIBER, Epidemiologia y Salud Publica, Barcelona, Spain. |
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