Document Detail


Association of leptin levels with radiographic knee osteoarthritis among a cohort of midlife women.
MedLine Citation:
PMID:  23281224     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To relate serum leptin levels to prevalent and incident radiographic knee osteoarthritis (OA) and to determine if patterns of change in longitudinal serum leptin measures differ by knee OA status over a 10-year period.
METHODS: Participants in the Michigan Study of Women's Health Across the Nation underwent bilateral knee radiographs at baseline and followup visits 2, 4, and 11 for ascertainment of knee OA status (Kellgren/Lawrence score ≥2). Serum leptin measures were available from baseline and followup visits 1 and 3-7.
RESULTS: The baseline prevalence of knee OA (mean age 46 years) was 18%; the 2-year incidence of knee OA at followup visits 2 and 4 was 18% and 14%, respectively. Serum leptin levels were associated with prevalent and incident knee OA. A 5 ng/ml increase in serum leptin level was associated with 38% higher odds of prevalent knee OA (odds ratio [OR] 1.38, 95% confidence interval [95% CI] 1.26-1.52) and 31% greater odds of incident knee OA (OR 1.31, 95% CI 1.21-1.41) after adjustment for covariates, including body mass index residuals. Leptin levels increased with time; on average, serum leptin levels increased by 0.38 ng/ml per year (P = 0.0004). Women with incident knee OA during the 10-year followup period had consistently higher serum leptin levels as compared to women with no knee OA during followup.
CONCLUSION: Our findings support a metabolic role of obesity in knee OA. A better understanding of the mechanisms by which increased fat mass is associated with joint damage is needed. Management of cardiometabolic dysfunction, including elevated serum leptin levels, may be beneficial in forestalling the onset or progression of knee OA.
Authors:
Carrie A Karvonen-Gutierrez; Siobán D Harlow; Peter Mancuso; Jon Jacobson; Carlos F Mendes de Leon; Bin Nan
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Arthritis care & research     Volume:  65     ISSN:  2151-4658     ISO Abbreviation:  Arthritis Care Res (Hoboken)     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-06-04     Completed Date:  2013-08-06     Revised Date:  2014-10-02    
Medline Journal Info:
Nlm Unique ID:  101518086     Medline TA:  Arthritis Care Res (Hoboken)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  936-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 by the American College of Rheumatology.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Body Mass Index
Cohort Studies
Disease Progression
Female
Follow-Up Studies
Humans
Incidence
Knee Joint / radiography*
Leptin / blood*
Longitudinal Studies
Michigan / epidemiology
Middle Aged
Osteoarthritis, Knee / blood,  epidemiology*,  radiography*
Prevalence
Women's Health*
Grant Support
ID/Acronym/Agency:
AG012495/AG/NIA NIH HHS; AG012505/AG/NIA NIH HHS; AG012531/AG/NIA NIH HHS; AG012535/AG/NIA NIH HHS; AG012539/AG/NIA NIH HHS; AG012546/AG/NIA NIH HHS; AG012553/AG/NIA NIH HHS; AG012554/AG/NIA NIH HHS; AG017104/AG/NIA NIH HHS; AG017719/AG/NIA NIH HHS; AG027708/AG/NIA NIH HHS; NR004061/NR/NINR NIH HHS; R01 AG017104/AG/NIA NIH HHS; R01 HL077417/HL/NHLBI NIH HHS; R24 HD041028/HD/NICHD NIH HHS; U01 AG012495/AG/NIA NIH HHS; U01 AG012505/AG/NIA NIH HHS; U01 AG012531/AG/NIA NIH HHS; U01 AG012535/AG/NIA NIH HHS; U01 AG012539/AG/NIA NIH HHS; U01 AG012546/AG/NIA NIH HHS; U01 AG012553/AG/NIA NIH HHS; U01 AG012554/AG/NIA NIH HHS; U01 AG017719/AG/NIA NIH HHS; U01 NR004061/NR/NINR NIH HHS
Chemical
Reg. No./Substance:
0/Leptin
Comments/Corrections

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