Document Detail


Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis.
MedLine Citation:
PMID:  23146889     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
With the steady rise in the prevalence of obesity and its associated diseases, research aimed at understanding the mechanisms that regulate and control whole body energy homeostasis has gained new interest. Leptin and insulin, two anorectic hormones, have key roles in the regulation of body weight and energy homeostasis, as highlighted by the fact that several obese patients develop resistance to these hormones. Within the brain, the hypothalamic proopiomelanocortin and agouti-related protein neurons have been identified as major targets of leptin and insulin action. Many studies have attempted to discern the individual contributions of various components of the principal pathways that mediate the central effects of leptin and insulin. The aim of this review is to discuss the latest findings that might shed light on, and lead to a better understanding of, energy balance and glucose homeostasis. In addition, recently discovered targets and mechanisms that mediate hormonal action in the brain are highlighted.
Authors:
Luis Varela; Tamas L Horvath
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-13
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-30     Completed Date:  2013-05-30     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  1079-86     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism,  secretion
Agouti-Related Protein* / genetics,  metabolism
Brain / metabolism
Energy Metabolism / genetics
Glucose / metabolism
Homeostasis / genetics
Humans
Insulin* / metabolism,  secretion
Leptin* / metabolism,  secretion
Obesity* / complications,  etiology,  metabolism
Proprotein Convertases* / genetics,  metabolism
Signal Transduction
Grant Support
ID/Acronym/Agency:
DP1 DK098058/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Agouti-Related Protein; 0/Insulin; 0/Leptin; EC 3.4.-/Proprotein Convertases; IY9XDZ35W2/Glucose
Comments/Corrections

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