Document Detail

Leptin induces tyrosine phosphorylation of cellular proteins including STAT-1 in human renal adenocarcinoma cells, ACHN.
MedLine Citation:
PMID:  8941366     Owner:  NLM     Status:  MEDLINE    
Several lines of evidence from in vivo animal experiments and human studies suggest that leptin, a peptide secreted from adipose tissue, plays a role in regulating food intake and energy expenditure. However, the signal transduction mechanism of leptin in its target cells remains unknown thus far since leptin-responsive cell lines have not been available yet. We found that leptin caused the tyrosine phosphorylation of several proteins in human renal cell carcinoma cells, ACHN cells, in which STAT-1, but neither STAT-3 nor STAT-5, was involved. An ACHN cell line would serve as a useful tool for analyzing the signal transduction mechanism of leptin.
Y Takahashi; Y Okimura; I Mizuno; T Takahashi; H Kaji; T Uchiyama; H Abe; K Chihara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  228     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1996 Nov 
Date Detail:
Created Date:  1997-01-06     Completed Date:  1997-01-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  859-64     Citation Subset:  IM    
Department of Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Adenocarcinoma / metabolism*,  pathology
Blotting, Western
DNA-Binding Proteins / metabolism*
Kidney Neoplasms / metabolism*,  pathology
Obesity / metabolism
Proteins / metabolism*
Recombinant Proteins / metabolism
STAT1 Transcription Factor
Trans-Activators / metabolism*
Tumor Cells, Cultured
Tyrosine / metabolism*
Reg. No./Substance:
0/DNA-Binding Proteins; 0/Leptin; 0/Proteins; 0/Recombinant Proteins; 0/STAT1 Transcription Factor; 0/STAT1 protein, human; 0/Trans-Activators; 55520-40-6/Tyrosine

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