Document Detail


Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism.
MedLine Citation:
PMID:  18925608     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: We describe a novel role of leptin in the fibrogenic process, the induction of phagocytosis of apoptotic bodies by hepatic stellate cells. The data provide strong evidence of a Rho-GTPase-mediated regulation of the cytoskeleton during stellate cell phagocytosis. Leptin-mediated phagocytic activity of stellate cells therefore could be an important mechanism responsible for progression of fibrosis in non-alcoholic steatohepatitis.
Authors:
Joy X Jiang; Kenichiro Mikami; Vijay H Shah; Natalie J Torok
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  48     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-04     Completed Date:  2008-11-18     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1497-505     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Gastroenterology and Hepatology, UC Davis Medical Center, Sacramento, CA 95817, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / drug effects*,  physiology
Cells, Cultured
DNA, Complementary / genetics
Humans
Leptin / pharmacology*
Liver / cytology,  drug effects,  enzymology,  physiology*
Male
Phagocytosis / drug effects*,  physiology
Rats
Rats, Zucker
Transfection
rac1 GTP-Binding Protein / genetics
rho GTP-Binding Proteins / metabolism*
Grant Support
ID/Acronym/Agency:
1 KO8 DK069765/DK/NIDDK NIH HHS; K08 DK069765/DK/NIDDK NIH HHS; K08 DK069765-04/DK/NIDDK NIH HHS; R01 DK059615/DK/NIDDK NIH HHS; R01 DK059615-09/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Leptin; EC 3.6.5.2/rac1 GTP-Binding Protein; EC 3.6.5.2/rho GTP-Binding Proteins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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