Document Detail

Leptin in relation to growth and developmental processes in the fetus.
MedLine Citation:
PMID:  12087497     Owner:  NLM     Status:  MEDLINE    
Leptin, a 16-kilodalton protein secreted by the adipose tissue in proportion to the amount of energy stored in adipose tissue, conveys to the hypothalamus information on energy homeostasis and regulates reproductive function. In addition, there is accumulating evidence that leptin produced by placental or fetal tissues acts through specific leptin receptors to regulate fetal growth and development. Although leptin levels are correlated with insulin and insulin-like growth factor (IGF)-1 levels, observational studies in humans indicate that its effects on fetal growth are independent of these axes and of adiposity. The extent to which leptin per se mediates the fetal growth and developmental abnormalities associated with disease states such as diabetes, hypoxia, or preeclampsia remains to be fully clarified by future studies in humans. It is hoped that clarification of these mechanisms may provide novel therapeutic approaches.
Helen Christou; Shanti Serdy; Christos S Mantzoros
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in reproductive medicine     Volume:  20     ISSN:  1526-8004     ISO Abbreviation:  Semin. Reprod. Med.     Publication Date:  2002 May 
Date Detail:
Created Date:  2002-06-27     Completed Date:  2002-11-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909394     Medline TA:  Semin Reprod Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  123-30     Citation Subset:  IM    
Division of Newborn Medicine, Children's Hospital, Boston, Massachusetts, USA.
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MeSH Terms
Bone Development
Brain / growth & development
Embryonic and Fetal Development*
Fetus / metabolism
Gene Expression
Leptin / biosynthesis,  physiology*
Neovascularization, Physiologic
Placenta / metabolism
Pregnancy Complications
Receptors, Cell Surface / genetics
Receptors, Leptin
Reproduction / physiology
Reg. No./Substance:
0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human

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