| Leptin in relation to growth and developmental processes in the fetus. | |
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MedLine Citation:
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PMID: 12087497 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin, a 16-kilodalton protein secreted by the adipose tissue in proportion to the amount of energy stored in adipose tissue, conveys to the hypothalamus information on energy homeostasis and regulates reproductive function. In addition, there is accumulating evidence that leptin produced by placental or fetal tissues acts through specific leptin receptors to regulate fetal growth and development. Although leptin levels are correlated with insulin and insulin-like growth factor (IGF)-1 levels, observational studies in humans indicate that its effects on fetal growth are independent of these axes and of adiposity. The extent to which leptin per se mediates the fetal growth and developmental abnormalities associated with disease states such as diabetes, hypoxia, or preeclampsia remains to be fully clarified by future studies in humans. It is hoped that clarification of these mechanisms may provide novel therapeutic approaches. |
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Authors:
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Helen Christou; Shanti Serdy; Christos S Mantzoros |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in reproductive medicine Volume: 20 ISSN: 1526-8004 ISO Abbreviation: Semin. Reprod. Med. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-06-27 Completed Date: 2002-11-27 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100909394 Medline TA: Semin Reprod Med Country: United States |
Other Details:
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Languages: eng Pagination: 123-30 Citation Subset: IM |
Affiliation:
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Division of Newborn Medicine, Children's Hospital, Boston, Massachusetts, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Development Brain / growth & development Embryonic and Fetal Development* Female Fetus / metabolism Gene Expression Hematopoiesis Humans Leptin / biosynthesis, physiology* Neovascularization, Physiologic Placenta / metabolism Pregnancy Pregnancy Complications Receptors, Cell Surface / genetics Receptors, Leptin Reproduction / physiology |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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