| Leptin in the newborn mouse. Plasma concentrations, characterization of the circulating hormone, and tissue source. | |
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MedLine Citation:
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PMID: 12169833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies suggested that brown adipose tissue (BAT) provides a source of circulating leptin in the newborn mouse. However, we detected no leptin mRNA in newborn BAT or in newborn liver or stomach. In contrast, leptin expression was detected readily in newborn white adipose tissue (WAT). Fasting plasma leptin concentrations in newborn mice were comparable to those in adult nonpregnant mice. In contrast to adult mice, however, the fasting leptin levels in newborn males were comparable to those in females. While leptin in the late-gestational pregnant mouse circulates as a complex with the leptin-binding protein, leptin in the newborn mouse circulates as the free hormone. Factors regulating the expression of leptin by newborn WAT remain to be elucidated. |
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Authors:
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Jon Oden; Don Fleenor; Phyllis Driscoll; Michael Freemark |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biology of the neonate Volume: 82 ISSN: 0006-3126 ISO Abbreviation: Biol. Neonate Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-08-09 Completed Date: 2003-03-18 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0247551 Medline TA: Biol Neonate Country: Switzerland |
Other Details:
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Languages: eng Pagination: 109-16 Citation Subset: IM |
Copyright Information:
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Copyright 2002 S. Karger AG, Basel |
Affiliation:
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Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism Adipose Tissue, Brown / metabolism Aging / metabolism Animals Animals, Newborn / metabolism* Blood / metabolism Female Leptin / genetics, metabolism* Liver / metabolism Male Mice Mice, Inbred C57BL Osmolar Concentration Pregnancy RNA, Messenger / metabolism Sex Characteristics Stomach / metabolism Tissue Distribution |
| Grant Support | |
ID/Acronym/Agency:
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HD24192/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/RNA, Messenger |
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