Document Detail

Leptin in bovine colostrum and milk.
MedLine Citation:
PMID:  16523408     Owner:  NLM     Status:  MEDLINE    
We studied leptin content in bovine colostrum, milk and plasma during the first month of lactation, and investigated relationships between selected milk components and milk leptin in five multiparous dairy cows. Colostrum/milk yield and composition were measured on days 0, 10, 20, and 30 of lactation. Leptin was assayed using a multi-species leptin RIA kit. Leptin concentration was 56 % lower in mature milk (day 10) than colostrum (13.90 vs. 6.14 microg/l; p < 0.001), but remained steady over the twenty days afterwards. Daily secretion of leptin into mature milk was 28 % lower than into colostrum (173.2 microg/d vs. 220.0 microg/d; p = 0.09) notwithstanding an 80 % increase in production. Colostrum and milk leptin levels correlated with fat (0.90; p < 0.001) and choline phospholipid (0.76; p < 0.05). Plasma and milk leptin decreased during the first month, but remained higher in milk, and highest in colostrum. Thus, leptin is present in large quantities in colostrum, less so and more variably in untreated milk, and is likely to be decreased in skimmed milk. These findings have implications for the use of untreated milk and colostrum-based (functional) food products.
L Pinotti; F Rosi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  38     ISSN:  0018-5043     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-05-18     Revised Date:  2009-02-19    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  89-93     Citation Subset:  IM    
Department of Veterinary Sciences and Technology for Food Safety, Veterinary Faculty, University of Milan, Italy.
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MeSH Terms
Colostrum / metabolism*
Lactation / metabolism*
Leptin / metabolism*
Parity / physiology
Pregnancy / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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