| Leptin gene and leptin receptor gene polymorphisms are associated with sweet preference and obesity. | |
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MedLine Citation:
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PMID: 18716353 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leptin is an adipocyte-secreted hormone that regulates food intake and body weight, and that was recently reported to suppress sweet sensitivity in an animal model. We investigated the associations among sweet preference, obesity, and polymorphisms of the leptin gene (LEP) or leptin receptor gene (LEPR). A total of 3,653 residents randomly selected from among the citizens of Suita City, Osaka, Japan were enlisted as subjects, in whom we investigated sweet preference, clinical characteristics, including obesity and serum leptin level, and the polymorphisms of LEP and LEPR (G-2548A and A19G for LEP; R109K, R223Q, and rs3790439 for LEPR). We determined the associations among the parameters using logistic regression analysis, in order to consider potential confounding factors for sweet preference and/or obesity. The LEP A19G and LEPR R109K polymorphisms were associated with sweet preference, whereas the serum leptin level was not. Further, the LEPR 109KK genotype was found to be associated with obesity along with sweet preference. In conclusion, our results are the first to show associations of LEP and LEPR polymorphisms with sweet preference, and may provide useful information for diagnosis and treatment of lifestyle-related diseases. |
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Authors:
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Einosuke Mizuta; Yoshihiro Kokubo; Itaru Yamanaka; Yoshihiro Miyamoto; Akira Okayama; Yasunao Yoshimasa; Hitonobu Tomoike; Hiroko Morisaki; Takayuki Morisaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension research : official journal of the Japanese Society of Hypertension Volume: 31 ISSN: 0916-9636 ISO Abbreviation: Hypertens. Res. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-08-21 Completed Date: 2008-09-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9307690 Medline TA: Hypertens Res Country: Japan |
Other Details:
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Languages: eng Pagination: 1069-77 Citation Subset: IM |
Affiliation:
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Department of Bioscience, National Cardiovascular Center Research Institute, Suita, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Calcium / metabolism Cholesterol, LDL / blood Female Food Preferences* Humans Leptin / genetics* Linkage Disequilibrium Male Middle Aged Obesity / etiology, genetics* Polymorphism, Genetic* Potassium Channels / physiology Receptors, Leptin / genetics* Taste |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, LDL; 0/Leptin; 0/Potassium Channels; 0/Receptors, Leptin; 7440-70-2/Calcium |
| Comments/Corrections | |
Comment In:
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Hypertens Res. 2008 Jun;31(6):1055-6
[PMID:
18716349
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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