| Leptin: fundamental aspects. | |
| | |
MedLine Citation:
|
PMID: 10193858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The discovery of leptin, the product of the ob gene, has led to major developments in understanding the regulation of energy balance. It is now recognised that leptin is produced in several organs additional to white adipose tissue, including brown fat, the placenta and fetal tissues (such as heart and bone/cartilage). The hormone has multiple functions-in inhibiting food intake, in the stimulation/maintenance of energy expenditure, as a signal to the reproductive system and as a 'metabolic' hormone influencing a range of processes (for example, insulin secretion, lipolysis, sugar transport). The production of leptin by white fat is subject to a number of regulatory influences, including insulin and glucocorticoids (which are stimulatory), and fasting and beta-adrenoceptor agonists (which are inhibitory). A key role in the regulation of leptin production by white fat is envisaged for the sympathetic system, operating through beta3-adrenoceptors. The leptin receptor gene is widely expressed, with the several splice variants exhibiting different patterns of expression. The long form variant (Ob-Rb) is expressed particularly in the hypothalamus, although it is being increasingly identified in other tissues. Leptin exerts its central effects through several neuroendocrine systems, including neuropeptide Y, glucagon-like peptide-1, melanocortins, corticotrophin releasing hormone (CRH) and cocaine- and amphetamine-regulated transcript (CART). In essence, the leptin system now appears highly complex, the hormone being involved in a range of physiological processes in a manner far transcending the initial lipostatic concept. This complexity may reduce the potential of the leptin system as a target for anti-obesity therapy. |
| | |
Authors:
|
P Trayhurn; N Hoggard; J G Mercer; D V Rayner |
Related Documents
:
|
20587058 - Momordica charantia (bitter melon) inhibits primary human adipocyte differentiation by ... 18293098 - Tissue expression of porcine foxo1 and its negative regulation during primary preadipoc... 10828068 - Transient induction of enc-1, a kelch-related actin-binding protein, is required for ad... 18835978 - Influence of chronic undernutrition and leptin on goat mrna levels in rat stomach mucosa. 1603088 - Thyroid hormone receptor mediates transcriptional activation and repression of differen... 9778688 - Role of gp55 in restoring the sensitivity of friend murine erythroleukemia cells to ery... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
|
Title: International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity Volume: 23 Suppl 1 ISSN: 0307-0565 ISO Abbreviation: Int. J. Obes. Relat. Metab. Disord. Publication Date: 1999 Feb |
Date Detail:
|
Created Date: 1999-05-24 Completed Date: 1999-05-24 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9313169 Medline TA: Int J Obes Relat Metab Disord Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 22-8 Citation Subset: IM |
Affiliation:
|
Division of Biomedical Science, Rowett Research Institute, Aberdeen, Scotland, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipose Tissue
/
physiology Animals Carrier Proteins / physiology Humans Leptin Obesity / genetics, physiopathology Proteins / genetics, physiology* Receptors, Cell Surface* Receptors, Leptin |
| Chemical | |
Reg. No./Substance:
|
0/Carrier Proteins; 0/Leptin; 0/Proteins; 0/Receptors, Cell Surface; 0/Receptors, Leptin; 0/leptin receptor, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Determinants of postprandial lipemia in obese women.
Next Document: Clinical endocrinology of human leptin.