Document Detail


Leptin expression in offspring is programmed by nutrition in pregnancy.
MedLine Citation:
PMID:  10828858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Birth weight is a determinant of blood leptin concentrations in adults. Since nutrition during pregnancy can affect birth weight, the hypothesis that feed intake during pregnancy alters leptin expression in progeny was examined. Leptin mRNA was measured in subcutaneous adipose tissue and leptin protein was measuredin blood plasma from 59 day old female pigs whose mothers were fed at the same restricted rate except that half were permitted to consume 35% more feed during the second quarter of pregnancy. Leptin mRNA abundance in adipose tissue (P=0.015) and plasma leptin concentration (P=0.01) were higher in progeny from mothers provided with more feed. Body weight at birth was negatively correlated with the abundance of leptin mRNA in subcutaneous fat at 59 days of age (P=0.01). This study shows for the first time that maternal nutrition during pregnancy programs postnatal leptin expression in offspring.
Authors:
J E Eckert; K L Gatford; B G Luxford; R G Campbell; P C Owens
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of endocrinology     Volume:  165     ISSN:  0022-0795     ISO Abbreviation:  J. Endocrinol.     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-08-29     Completed Date:  2000-08-29     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0375363     Medline TA:  J Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  R1-6     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide 5005, Australia.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism
Animal Nutritional Physiological Phenomena*
Animals
Birth Weight / physiology
Female
Leptin / blood,  genetics,  metabolism*
Pregnancy
Pregnancy, Animal / physiology*
Prenatal Exposure Delayed Effects*
RNA, Messenger / genetics
Reverse Transcriptase Polymerase Chain Reaction
Chemical
Reg. No./Substance:
0/Leptin; 0/RNA, Messenger

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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