Document Detail


Leptin, corticotropin-releasing hormone (CRH), and neuropeptide Y (NPY)in free-ranging pregnant bats.
MedLine Citation:
PMID:  9549039     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leptin, the product of the obese gene first identified in mice, restores fertility in obese mice, and accelerates puberty in mice. We hypothesized that leptin's putative role in reproduction may extend to pregnancy and lactation. Leptin levels were determined in Myotis lucifugus, the little brown bat, a free-ranging mammal with a seasonal breeding cycle. The present study shows that plasma levels of leptin progressively rise during pregnancy, supporting a potential role for leptin in the maintenancy of pregnancy. In contrast, leptin was significantly lower during lactation, a time when most mammals, including bats, demonstrate reduced fertility. In addition to its possible roles in reproduction, leptin appears important in regulation of energy balance. M. lucifugus spontaneously fasts for up to 16 h each day during the active season, which allowed us to test the hypothesis that acute fasting was associated with decreased leptin. Leptin was significantly lower in fasted (lactating) bats, compared to those that recently returned from nightly foraging. Although postprandial lactating bats had a significantly higher fat index than fasted bats, plasma leptin and body fat were not significantly correlated, and were only weakly correlated (r2 = 0.26) when both pregnant and lactating females were included in the analysis. Similar changes during pregnancy, lactation, and the daily feeding cycle were observed in the hypothalamic neuropeptide, corticotropin-releasing hormone (CRH), which is believed to play an important role in energy balance and reproduction. By contrast, neuropeptide Y (NPY) increased during pregnancy but did not change during fasting. These results suggest that leptin's putative role in reproduction may extend to pregnancy and lactation, and that spontaneous, acute fasting results in decreased circulating levels of leptin in M. lucifugus.
Authors:
E P Widmaier; J Long; B Cadigan; S Gurgel; T H Kunz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Endocrine     Volume:  7     ISSN:  1355-008X     ISO Abbreviation:  Endocrine     Publication Date:  1997 Oct 
Date Detail:
Created Date:  1998-05-22     Completed Date:  1998-05-22     Revised Date:  2010-06-24    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
Affiliation:
Department of Biology, Boston University, Boston, MA, USA. widmaier@bio.bu.edu
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue
Animals
Body Composition
Chiroptera / metabolism*
Corticotropin-Releasing Hormone / metabolism*
Female
Hydrocortisone / blood
Hypothalamus / metabolism
Lactation / physiology
Leptin
Male
Neuropeptide Y / metabolism*
Pregnancy
Pregnancy, Animal / metabolism*
Proteins / metabolism*
Chemical
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y; 0/Proteins; 50-23-7/Hydrocortisone; 9015-71-8/Corticotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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