Document Detail

Leptin blocks the fasting-induced increase of pERK1/2 in the paraventricular nucleus of rats.
MedLine Citation:
PMID:  20346990     Owner:  NLM     Status:  MEDLINE    
This study was conducted to define molecular mechanisms by which food deprivation increases phosphorylated extracellular signal-regulated protein kinase (pERK1/2) in the hypothalamic paraventricular nucleus of rats. pERK1/2 immunoreactivity (-ir) is markedly increased in the paraventricular nucleus by 48h of food deprivation. Treatment with RU486, glucocorticoid antagonists, during food deprivation did not affect the fasting-induced increase of pERK1/2-ir in the paraventricular nucleus, but intracerebroventricular (icv) leptin blocked the increase of pERK1/2-ir by food deprivation. Fasting-induced increases of neuropeptide Y (NPY) expression both in the arcuate nucleus and the paraventricular nucleus were also blunted by icv leptin; however, the icv NPY to satiated rats did not increase pERK1/2 in the paraventricular nucleus. These results suggest that the fasting-induced increase of pERK1/2 in the paraventricular nucleus may not be mediated either by plasma corticosterone or the hypothalamic NPY, but require leptin dis-inhibition.
Jong-Ho Lee; Mi Joo Cha; Sang Bae Yoo; Young Wha Moon; Seung June Noh; Jeong Won Jahng
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-03-25
Journal Detail:
Title:  Regulatory peptides     Volume:  162     ISSN:  1873-1686     ISO Abbreviation:  Regul. Pept.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8100479     Medline TA:  Regul Pept     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  122-8     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier B.V. All rights reserved.
Department of Oral and Maxillofacial Surgery, Dental Research Institute, Seoul National University School of Dentistry, Seoul, 110-768, Republic of Korea.
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MeSH Terms
Blotting, Western
Extracellular Signal-Regulated MAP Kinases / metabolism*
Fluorescent Antibody Technique
In Situ Hybridization
Leptin / pharmacology*
Neuropeptide Y / metabolism
Paraventricular Hypothalamic Nucleus / drug effects*,  enzymology
Rats, Sprague-Dawley
Reg. No./Substance:
0/Leptin; 0/Neuropeptide Y; EC Signal-Regulated MAP Kinases

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