| Leptin is associated with the size of the apolipoprotein(a) particle in African tribal populations living on fish or vegetarian diet. | |
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MedLine Citation:
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PMID: 20197188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Apolipoprotein(a) [or apo(a)] isoform size, which is strongly genetically determined, showed significant association with the cardiovascular risk. Subjects on a fish diet have lower lipoprotein(a) levels, larger apo(a) isoform sizes and lower leptin levels than their vegetarian diet counterparts. We hypothesized that leptin may contribute to a potential association between the type of diet and the size of apo(a) isoforms. METHODS: Anthropometric data, dietary nutrients, lipoprotein profile, plasma leptin levels, and apo(a) isoforms were evaluated in two related homogenous African tribal populations of Tanzania, one on a primarily freshwater fish diet (n=278), and the other on a vegetarian diet (n=326). RESULTS: We observed a strong negative association between leptin levels and size of each of the apo(a) isoforms in both fish and vegetable diet groups, and in both genders. However, leptin was not associated with levels of lipoprotein(a). In multivariate analysis, a strong and independent association between leptin and size of apo(a) isoforms was observed. The size of apo(a) isoforms was strongly associated with high and low leptin states. Subjects with low leptins had 30% larger sizes of apo(a) isoforms than their high leptin counterparts. CONCLUSIONS: High leptin subjects have smaller, potentially more atherogenic, apo(a) isoform sizes than low leptin ones. We suggest that omega-3 rich diet can influence the levels of apo(a) and/or Lp(a) even though they are mainly genetically determined. These findings may have implications for understanding the interaction between leptin and cardiovascular risk. |
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Authors:
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Mikolaj Winnicki; Massimo Puato; Virend K Somers; Alberto Zambon; Santica M Marcovina; Marcello Rattazzi; Bradley G Phillips; Paolo Pauletto |
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Publication Detail:
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Type: Journal Article Date: 2010-02-04 |
Journal Detail:
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Title: Atherosclerosis Volume: 211 ISSN: 1879-1484 ISO Abbreviation: Atherosclerosis Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 303-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Medical University of Gdansk, Poland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult African Continental Ancestry Group* Animals Apolipoproteins A / blood* Cardiovascular Diseases / etiology Diet* Diet, Vegetarian* Ethnic Groups* Fatty Acids, Omega-3 / pharmacology Female Fishes* Food Habits* Humans Leptin / blood* Male Middle Aged Protein Isoforms / blood* Risk Factors Tanzania |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins A; 0/Fatty Acids, Omega-3; 0/Leptin; 0/Protein Isoforms |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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