| Leptin as a physiological mediator of energetic trade-offs in ecoimmunology: implications for disease. | |
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MedLine Citation:
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PMID: 21940777 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Organisms must distribute sufficient energy among different and often competing physiological systems. This task can become challenging, however, as resources are often limiting, resulting in energetic trade-offs. For example, energetically based trade-offs between the reproductive and immune systems are common across taxa, yet the regulatory mechanisms underlying these trade-offs remain unclear. The adipose tissue hormone leptin is an ideal candidate for the modulation of energetic trade-offs between different physiological systems as this hormone serves as a gage of fat reserves and also modulates a range of physiological activities including the reproductive and immune processes. This article presents a review of the evidence for the role of leptin as a modulator of energetic trade-offs with the immune system and suggests its importance in disease ecology. In addition, we provide a case study of the ornate tree lizard (Urosaurus ornatus), testing whether leptin is involved in mediating a well-documented influence of energy state on the trade-off between reproductive activity and immune function. Overall, the combined results suggest that leptin serves as a proximate endocrine signal of available energy to the immune system, and therefore likely to affect susceptibility to diseases. |
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Authors:
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Susannah S French; M Denise Dearing; Gregory E Demas |
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Publication Detail:
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Type: Journal Article Date: 2011-05-05 |
Journal Detail:
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Title: Integrative and comparative biology Volume: 51 ISSN: 1557-7023 ISO Abbreviation: Integr. Comp. Biol. Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-09-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101152341 Medline TA: Integr Comp Biol Country: England |
Other Details:
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Languages: eng Pagination: 505-13 Citation Subset: IM |
Affiliation:
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*Department of Biology, Utah State University, 5305 Old Main Hill, Logan, UT 84322-5305, USA; Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, Utah 84112; Department of Biology, Center for the Integrative Study of Animal Behavior, Indiana University, 1001 E. 3rd Street, Bloomington, IN 47405-3700, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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