| Leptin administration to overweight and obese subjects for 6 months increases free leptin concentrations but does not alter circulating hormones of the thyroid and IGF axes during weight loss induced by a mild hypocaloric diet. | |
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MedLine Citation:
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PMID: 21602313 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Short-term energy deprivation reduces leptin concentrations and alters the levels of circulating hormones of the hypothalamic-pituitary-peripheral axis in lean subjects. Whether the reduction in leptin concentration during long-term weight loss in obese individuals is linked to the same neuroendocrine changes seen in lean, leptin-sensitive subjects remains to be fully clarified. METHODS: In this study, 24 overweight and obese adults (16 women and eight men; body mass index (BMI): 27.5-38.0 kg/m(2)) were prescribed a hypocaloric diet (-500 kcal/day) and were randomized to receive recombinant methionyl leptin (n=18, metreleptin, 10 mg/day self-injected s.c.) or placebo (n=6, same volume and time as metreleptin) for 6 months. RESULTS: Metreleptin administration did not affect weight loss beyond that induced by hypocaloric diet alone (P for interaction=0.341) but increased the serum concentrations of total leptin by six- to eight-fold (P<0.001) and led to the generation of anti-leptin antibodies. Despite free leptin concentration (P for interaction=0.041) increasing from 9±1 ng/ml at baseline to 43±15 and 36±12 ng/ml at 3 and 6 months, respectively, changes in circulating hormones of the thyroid and IGF axes at 3 and 6 months were not significantly different in the placebo- and metreleptin-treated groups. CONCLUSIONS: Leptin does not likely mediate changes in neuroendocrine function in response to weight loss induced by a mild hypocaloric diet in overweight and obese subjects. |
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Authors:
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Greeshma K Shetty; Giuseppe Matarese; Faidon Magkos; Hyun-Seuk Moon; Xiaowen Liu; Aoife M Brennan; Geetha Mylvaganam; Despina Sykoutri; Alex M Depaoli; Christos S Mantzoros |
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Publication Detail:
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Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-05-20 |
Journal Detail:
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Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 165 ISSN: 1479-683X ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-07-12 Completed Date: 2011-09-09 Revised Date: 2012-03-21 |
Medline Journal Info:
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Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
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Languages: eng Pagination: 249-54 Citation Subset: IM |
Affiliation:
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Division of Endocrinology, Diabetes and Metabolism, Harvard Medical School and Harvard School of Public Health, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Caloric Restriction Diet, Reducing Drug Administration Schedule Female Humans Leptin / administration & dosage*, blood* Male Middle Aged Obesity / blood, diet therapy*, drug therapy* Osmolar Concentration Overweight / blood, diet therapy*, drug therapy* Signal Transduction / drug effects Somatomedins / analysis* Thyroid Gland / drug effects, metabolism Thyroid Hormones / blood* Time Factors Weight Loss / drug effects Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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AG032030/AG/NIA NIH HHS; DK081913/DK/NIDDK NIH HHS; DK58785/DK/NIDDK NIH HHS; DK79929/DK/NIDDK NIH HHS; F32 DK64550-01A1/DK/NIDDK NIH HHS; GJT08004//Telethon; K24 DK081913-03/DK/NIDDK NIH HHS; R01 AG032030-03/AG/NIA NIH HHS; R01 AG032030-04/AG/NIA NIH HHS; R01 DK058785-02/DK/NIDDK NIH HHS; R01 DK079929-03/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Somatomedins; 0/Thyroid Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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