| Leptin, adiponectin, visfatin and retinol-binding protein-4 - mediators of comorbidities in patients with psoriasis? | |
| | |
MedLine Citation:
|
PMID: 22151390 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
White adipose tissue is known to be involved in numerous physiological processes such as insulin-mediated functions, lipid and glucose metabolism, vascular changes and coagulation. These processes are mainly mediated by adipokines that are secreted either from adipocytes or cells of the stromal-vascular fraction of adipose tissue. In obesity, a shift in the production of adipokines can mediate the development of associated diseases, such as metabolic syndrome, and vascular complications, such as artherosclerosis, myocardial infarction or stroke, which are known comorbidities of psoriasis too. As obesity is a frequently seen comorbidity in psoriasis patients, adipokines could be involved in the pathogenesis of psoriasis and/or its comorbidities either dependently or independently from obesity. Therefore, this study investigates the levels of four major adipokines in psoriasis patients compared with a control group of healthy volunteers without chronic inflammatory diseases in relation to body composition. Leptin, adiponectin (high molecular weight (HMW) and total adiponectin), visfatin and retinol-binding protein 4 (RBP4) have been analysed in 79 psoriasis patients and in 80 healthy volunteers. It was shown that HMW adiponectin (OR 1.3755; P = 0.0094) and visfatin (OR 1.1267; P = 0.0472) are independently increased, and RBP4 (OR 0.9884; P < 0.0001) is independently decreased in psoriasis. In conclusion, increased levels of HMW adiponectin and decreased levels of RBP4 could be a mechanism in a chronic inflammatory state that helps to protect against vascular and metabolic disorders, whereas the increase of the pro-inflammatory adipokine visfatin could lead to atherosclerosis and vascular disorders found in psoriasis. |
| | |
Authors:
|
Sascha Gerdes; Svetlana Osadtschy; Martin Rostami-Yazdi; Norbert Buhles; Michael Weichenthal; Ulrich Mrowietz |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Experimental dermatology Volume: 21 ISSN: 1600-0625 ISO Abbreviation: Exp. Dermatol. Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9301549 Medline TA: Exp Dermatol Country: Denmark |
Other Details:
|
Languages: eng Pagination: 43-7 Citation Subset: IM |
Copyright Information:
|
© 2011 John Wiley & Sons A/S. |
Affiliation:
|
Psoriasis-Center at the Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Kiel, Germany Asklepios-Nordseeklinik, Westerland/Sylt, Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: In vivo assessment of peripheral vascular function by tcpo2 and skin blood flow modelling.
Next Document: Non-invasive evaluation of dermal elastosis by in vivo multiphoton tomography with autofluorescence ...