Document Detail


Leptin-activity blockers: development and potential use in experimental biology and medicine.
MedLine Citation:
PMID:  24117254     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The first adipokine, leptin, discovered almost 20 years ago, is secreted into circulation mainly from adipose tissue and acts both centrally and peripherally. Leptin regulates energy metabolism, reproductive function, bone metabolism, and immune response. However in some physiological or pathological situations such as enhancement of undesired immune responses in autoimmune diseases, tumorigenesis, elevated blood pressure, and certain cardiovascular pathologies, leptin activity may be harmful. In this review we screen different approaches to blocking leptin action, in vitro and in vivo. The recent development of superactive leptin muteins exhibiting antagonistic properties, and other leptin-action-blocking peptides, proteins, monoclonal antibodies, and nanobodies, opens new perspectives for their use in research, and eventually, therapy for cachexia, autoimmune disease, cancer, and other pathologies.
Authors:
Arieh Gertler; Gili Solomon
Related Documents :
24394954 - In silico identification of potential therapeutic targets in the tgf-β signal transduct...
24669264 - Yanshu spraying agent, a traditional chinese medicine, relieves chronic pharyngitis in ...
23604884 - Role of xanthine dehydrogenase and aging on the innate immune response of drosophila.
24180744 - Inflammatory responses in primary muscle cell cultures in atlantic salmon (salmo salar).
16008674 - Effects of various anti-asthmatic agents on mite allergen-pulsed murine bone marrow-der...
24462584 - Tetramethylpyrazine analogue cxc195 protects against cerebral ischemia/reperfusion-indu...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-4-22
Journal Detail:
Title:  Canadian journal of physiology and pharmacology     Volume:  91     ISSN:  1205-7541     ISO Abbreviation:  Can. J. Physiol. Pharmacol.     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-10-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372712     Medline TA:  Can J Physiol Pharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  873-882     Citation Subset:  -    
Affiliation:
The Institute of Biochemistry, Food Science, and Nutrition, The Hebrew University of Jerusalem, P.O. Box 12, Rehovot 76100, Israel.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Metabolic inflammation: role of cytokines in the crosstalk between adipose tissue and liver.
Next Document:  The potential contribution of circulating and locally produced leptin to cardiac hypertrophy and fai...