Document Detail


Leptin and the placental response to maternal food restriction during early pregnancy in mice.
MedLine Citation:
PMID:  22993381     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several studies have demonstrated that maternal undernutrition or overnutrition during pregnancy can have negative consequences for the health of children born to these pregnancies, but the physiological mechanisms by which this occurs are not completely understood. During periods of food restriction, concentrations of leptin decline, whereas leptin is elevated in obesity, suggesting that it may play a role in the response to altered nutrition during pregnancy. This study compares placental development and global placental gene expression profiles at Day 11.5 in pregnant control mice, mice that were undernourished, and mice that were undernourished but given leptin. Placentas from mothers exposed to food restriction preserved the placental labyrinth zone at the expense of the junctional zone, an effect abrogated in the restricted plus leptin group, which had a significant decrease in the labyrinth zone area compared with controls. Similarly, there were more significant differences in gene expression between placentas from control and restricted plus leptin mothers (1128 differentially expressed genes) than between placentas of control and restricted mothers (281 differentially expressed genes). We conclude that the presence of high concentrations of circulating leptin during food restriction disrupts the normal adaptive response of the placenta to reduced energy availability.
Authors:
Laura Clamon Schulz; Jessica M Schlitt; Gerialisa Caesar; Kathleen A Pennington
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-11-16
Journal Detail:
Title:  Biology of reproduction     Volume:  87     ISSN:  1529-7268     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-19     Completed Date:  2013-04-22     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120     Citation Subset:  IM    
Affiliation:
Department of Obstetrics, Gynecology and Women's Health, University of Missouri, Columbia, Missouri, USA. schulzl@missouri.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animal Nutritional Physiological Phenomena
Animals
Female
Fetal Weight
Food Deprivation / physiology*
Gestational Age
Leptin / administration & dosage,  blood,  physiology*
Malnutrition / complications,  pathology,  physiopathology
Maternal Nutritional Physiological Phenomena
Mice
Microarray Analysis
Organ Size
Placenta / pathology,  physiology*
Pregnancy
Pregnancy Complications / pathology,  physiopathology
Transcriptome
Grant Support
ID/Acronym/Agency:
HD055231/HD/NICHD NIH HHS; R00 HD055231/HD/NICHD NIH HHS; R25 GM056901/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Leptin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Use of Pretreatment Metabolic Tumor Volumes on PET-CT to Predict the Survival of Patients with Squam...
Next Document:  The reproductive phenotype of mice null for transcription factor Krüppel-like factor 13 suggests co...