| Leptin on peritoneal macrophages of patients with endometriosis. | |
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MedLine Citation:
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PMID: 20047585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PROBLEM: The expression of cyclooxygenase (COX)-2 is considered as a marker of macrophage activation and has been implicated in the development of endometriosis. Leptin is an immunomodulator, which may also affect the development of endometriosis. However, how leptin contributes to these pathological processes has not been completely understood. The aim of this study was to investigate the effects of leptin on peritoneal macrophages and its relationship with endometriosis. METHODS OF STUDY: Peritoneal fluid from 60 women of reproductive age was obtained while they underwent laparoscopy. Forty patients had endometriosis and 20 patients did not have endometriosis. The concentration of leptin in the peritoneal fluid and prostaglandin F(2alpha) levels was measured by ELISA, and the other protein expression using Western blot when peritoneal macrophages were stimulated with leptin. RESULTS: Concentration of leptin in peritoneal fluid was increased in patients with endometriosis compared with disease-free normal control. Functional leptin receptor was present in peritoneal macrophages. Treatment of peritoneal macrophages with leptin induced COX-2 expression. Production of prostaglandin F(2alpha) by peritoneal macrophages was increased after leptin stimulation in women with endometriosis. CONCLUSION: Elevated concentration of leptin in peritoneal fluid may contribute to the pathological process of endometriosis through activation of peritoneal macrophages. |
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Authors:
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Meng-Hsing Wu; Mei-Feng Huang; Fong-Ming Chang; Shaw-Jenq Tsai |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-29 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 63 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-12 Completed Date: 2010-03-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 214-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, College of Medicine, National Cheng Kung University, 1 University Road, Tainan, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Ascitic Fluid / immunology Cyclooxygenase 2 / immunology Dinoprost / immunology Endometriosis / immunology* Female Humans Interleukin-1 / immunology Leptin / immunology* Macrophage-Activating Factors / immunology Macrophages, Peritoneal / immunology* Receptors, Interleukin-1 / immunology STAT3 Transcription Factor / immunology Taiwan |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; 0/Leptin; 0/Macrophage-Activating Factors; 0/Receptors, Interleukin-1; 0/STAT3 Transcription Factor; 0/STAT3 protein, human; 551-11-1/Dinoprost; EC 1.14.99.1/Cyclooxygenase 2; EC 1.14.99.1/PTGS2 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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