Document Detail


Leptin, not adiponectin, predicts hypertension in the Copenhagen City Heart Study.
MedLine Citation:
PMID:  20019673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Leptin and adiponectin are hormones secreted by adipose tissue, and both hormones are candidate intermediaries between adipose tissue and overweight-related diseases. So far, no prospective study has been published where the independent effects of these two hormones on the development of hypertension have been directly compared. The objective of this study was to investigate the relationships between plasma levels of leptin and adiponectin and new-onset hypertension in the Copenhagen City Heart Study (CCHS).
METHODS: In a prospective study design, we examined new-onset hypertension in 620 women and 300 men who were normotensive in the third CCHS examination, which was performed in 1991-1994.
RESULTS: Between the third and the fourth CCHS examination, which was performed in 2001-2003, 254 had developed hypertension, defined as systolic blood pressure (SBP) > or = 140 mm Hg, or diastolic blood pressure (DBP) > or = 90 mm Hg, or use of antihypertensive medication. Using logistic regression analysis, adjusting for age, sex, estimated glomerular filtration rate, triglycerides, high-density lipoprotein cholesterol (HDL-C), fibrinogen, and glucose, and with leptin and adiponectin included in the same model, leptin was significantly associated with new-onset hypertension with an odds ratio (95% confidence interval) of 1.28 (1.08-1.53; P < 0.005) for 1 s.d. higher level of log-transformed leptin, whereas adiponectin was not significantly associated with new-onset hypertension having an odds ratio of 1.02 (0.84-1.24; P = 0.83) for 1 s.d. higher level of log-transformed adiponectin.
CONCLUSIONS: In the CCHS, leptin, but not adiponectin, was a significant independent predictor of new-onset hypertension.
Authors:
Camilla Asferg; Rasmus Møgelvang; Allan Flyvbjerg; Jan Frystyk; Jan S Jensen; Jacob L Marott; Merete Appleyard; Gorm B Jensen; Jørgen Jeppesen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-12-17
Journal Detail:
Title:  American journal of hypertension     Volume:  23     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-15     Completed Date:  2010-04-29     Revised Date:  2011-06-30    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
Affiliation:
Department of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Glostrup, Denmark. caluas03@glo.regionh.dk
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MeSH Terms
Descriptor/Qualifier:
Adiponectin / blood*
Adult
Biological Markers / blood
Denmark
Female
Humans
Hypertension / blood*,  diagnosis*
Leptin / blood*
Male
Middle Aged
Prognosis
Chemical
Reg. No./Substance:
0/Adiponectin; 0/Biological Markers; 0/Leptin
Comments/Corrections
Comment In:
Am J Hypertens. 2010 Aug;23(8):814; author reply 815   [PMID:  20644526 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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