Document Detail

Leptin, mild cognitive impairment, and dementia among elderly women.
MedLine Citation:
PMID:  22859388     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The association between obesity and dementia has been inconsistent, possibly due to changes in body composition often seen in old age. Leptin may be associated with better cognitive function. However, neuroprotection may be inhibited among obese subjects possibly due to leptin resistance. We sought to determine (i) if leptin is associated with risk of dementia or mild cognitive impairment (MCI) in a cohort of very old women, (ii) if this association is modified by obesity, and (iii) if leptin is a stronger risk factor compared with traditional anthropometric measures.
METHODS: We studied 579 older women (mean age 82.6 years) from the ongoing prospective cohort Study of Osteoporotic Fractures, who were dementia-free at year-16 examination (our study baseline). Leptin (ng/mL) was measured using year-16 frozen serum, and anthropometric measures were collected during the same visit. Diagnosis of dementia/MCI was determined at year-20 examination.
RESULTS: There was evidence for a multiplicative interaction between log leptin and categorical body mass index (p = .03). Among women with body mass index <25kg/m(2) (n = 190), 1SD difference in log leptin (0.91ng/mL) was associated with 32% lower odds of dementia/MCI (OR = .68; 95% CI = .46, .99), after adjustment. The association was not significant among women with body mass index ≥25kg/m(2) (n = 377). Traditional anthropometric measures such as weight, height, and body mass index were not associated with dementia/MCI.
CONCLUSIONS: In this cohort of very old women, higher serum leptin was prospectively associated with lower odds of dementia/MCI in women with normal body mass index, but not in overweight or obese women. Leptin may be a better predictor of dementia/MCI than traditional anthropometric measures.
Adina Zeki Al Hazzouri; Katie L Stone; Mary N Haan; Kristine Yaffe
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-08-02
Journal Detail:
Title:  The journals of gerontology. Series A, Biological sciences and medical sciences     Volume:  68     ISSN:  1758-535X     ISO Abbreviation:  J. Gerontol. A Biol. Sci. Med. Sci.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2012-12-24     Completed Date:  2013-02-20     Revised Date:  2014-05-14    
Medline Journal Info:
Nlm Unique ID:  9502837     Medline TA:  J Gerontol A Biol Sci Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-80     Citation Subset:  AIM; IM    
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MeSH Terms
Aged, 80 and over
Aging / blood,  pathology
Biological Markers / blood
Body Mass Index
Cohort Studies
Dementia / blood*,  complications,  pathology
Leptin / blood*
Mild Cognitive Impairment / blood*,  complications,  pathology
Obesity / blood,  complications,  pathology
Odds Ratio
Overweight / blood,  complications,  pathology
Prospective Studies
Risk Factors
United States
Grant Support
K24 AG031155/AG/NIA NIH HHS; R01 AG005394/AG/NIA NIH HHS; R01 AG005407/AG/NIA NIH HHS; R01 AG012975/AG/NIA NIH HHS; R01 AG026720/AG/NIA NIH HHS; R01 AG026720/AG/NIA NIH HHS; R01 AG027574/AG/NIA NIH HHS; R01 AG027576/AG/NIA NIH HHS; R01 AR35582/AR/NIAMS NIH HHS; R01 AR35583/AR/NIAMS NIH HHS; R01 AR35584/AR/NIAMS NIH HHS
Reg. No./Substance:
0/Biological Markers; 0/Leptin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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