Document Detail

Leptin and IGF-I levels in unconditioned male volunteers after short-term exercise.
MedLine Citation:
PMID:  10818280     Owner:  NLM     Status:  MEDLINE    
We have previously shown that serum gonadotropins, particularly LH, decline after acute exercise in male volunteers. The mechanism for this decline is unknown. Plasma leptin and IGF-I concentrations were measured in seven male volunteers after acute exercise to exhaustion using the Bruce protocol. Leptin concentrations declined following exercise reaching nadir values 30-120 min after exercise. As anticipated, plasma IGF-I concentrations showed a transient rise immediately after exercise falling thereafter to nadir levels 60-90 min after exercise before returning towards baseline levels. In view of the previously described decline in gonadotropin release after acute exercise, the decline in plasma leptin levels, perhaps related to the rise in IGF-I, may play a role in exercise-induced inhibition of gonadotropin release presumably by inhibition of GnRH secretion.
A N Elias; M R Pandian; L Wang; E Suarez; N James; A F Wilson
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Psychoneuroendocrinology     Volume:  25     ISSN:  0306-4530     ISO Abbreviation:  Psychoneuroendocrinology     Publication Date:  2000 Jul 
Date Detail:
Created Date:  2000-08-03     Completed Date:  2000-08-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7612148     Medline TA:  Psychoneuroendocrinology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  453-61     Citation Subset:  IM    
Department of Medicine, Division of Endocrinology, UC, Irvine, CA 92717, USA.
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MeSH Terms
Exercise / physiology*
Insulin-Like Growth Factor I / metabolism*
Leptin / metabolism*
Middle Aged
Reg. No./Substance:
0/Leptin; 67763-96-6/Insulin-Like Growth Factor I

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