Document Detail


Lepirudin for treatment of acute thrombosis during pregnancy.
MedLine Citation:
PMID:  18669753     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Thromboprophylaxis during pregnancy can be challenging when heparin is contraindicated. Limited data exist regarding alternative anticoagulants in the setting of pregnancy. CASE: We present a patient with antiphospholipid syndrome who developed heparin-induced thrombosis in the third trimester of pregnancy. She was treated with therapeutic doses of intravenous lepirudin until delivery. Induction of labor, regional anesthesia, and forceps-assisted vaginal delivery were performed with no fetal, neonatal, or maternal complications. Postpartum, the patient was transitioned to warfarin therapy, and at 6 weeks postdelivery neither the patient nor her infant had developed any new problems. CONCLUSION: Intravenous lepirudin use at therapeutic doses in late gestation as an alternative to heparin was accomplished with minimal maternal and fetal morbidity.
Authors:
Moncenya L Chapman; Anibal R Martinez-Borges; Heather L Mertz
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  112     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-01     Completed Date:  2008-09-09     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  432-3     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA.
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MeSH Terms
Descriptor/Qualifier:
Anticoagulants / adverse effects,  therapeutic use*
Female
Heparin / adverse effects
Hirudins
Humans
Infusions, Intravenous
Pregnancy
Pregnancy Complications, Cardiovascular / chemically induced,  drug therapy*
Pregnancy Trimester, Third
Recombinant Proteins / therapeutic use
Venous Thrombosis / chemically induced,  drug therapy*
Chemical
Reg. No./Substance:
0/Anticoagulants; 0/Hirudins; 0/Recombinant Proteins; 0/lepirudin; 9005-49-6/Heparin
Comments/Corrections
Comment In:
Obstet Gynecol. 2008 Aug;112(2 Pt 2):419-20   [PMID:  18669748 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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