Document Detail

Lepidium meyenii (Maca) reversed the lead acetate induced -- damage on reproductive function in male rats.
MedLine Citation:
PMID:  16510228     Owner:  NLM     Status:  MEDLINE    
Rats were treated with 0, 8, 16 and 24 mg/kg of lead acetate (LA) (i.p.) for 35 days with or without Maca. Maca was co-administrated orally from day 18 to day 35. The lengths of stages of the seminiferous epithelium were assessed by transillumination. Also, sex organ weights, testicular and epididymal sperm count, sperm motility, daily sperm production, sperm transit rate and serum testosterone levels were measured. Lead acetate treatment resulted in a dose-response reduction of lengths of stages VIII and IX-XI, and serum testosterone levels. However, rats treated with 8 and 16 mg/kg but not 24 mg/kg of lead acetate showed a low number of testicular spermatids, low daily sperm production (DSP) and low epididymal sperm count. Administration of Maca to rats treated with lead acetate resulted in higher lengths of stages VIII and IX-XI with respect to lead acetate-treated rats. Moreover, treatment with Maca to lead acetate-treated rats resulted in lengths of stages VIII and IX-XI similar to the control group. Maca administration also reduced the deleterious effect on DSP caused by lead acetate treatment. Maca prevented LA-induced spermatogenic disruption in rats and it may become in a potential treatment of male infertility associated with lead exposure.
Julio Rubio; Marissa I Riqueros; Manuel Gasco; Sandra Yucra; Sara Miranda; Gustavo F Gonzales
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2006-02-28
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  44     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-13     Completed Date:  2006-08-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1114-22     Citation Subset:  IM    
Department of Biological and Physiological Sciences, Faculty of Sciences and Philosophy, Universidad Peruana Cayetano Heredia, Lima, Peru.
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MeSH Terms
Epididymis / cytology
Genitalia, Male / drug effects
Lepidium / chemistry*
Organ Size / drug effects
Organometallic Compounds / antagonists & inhibitors*,  toxicity*
Plant Extracts / pharmacology
Rats, Sprague-Dawley
Reproduction / drug effects*
Sperm Count
Sperm Motility / drug effects
Testosterone / blood
Grant Support
5-D43TW005746-04/TW/FIC NIH HHS
Reg. No./Substance:
0/Organometallic Compounds; 0/Plant Extracts; 301-04-2/lead acetate; 58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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