| Lentivirus as a tool for lineage-specific gene manipulations. | |
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MedLine Citation:
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PMID: 17607693 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The trophectoderm (TE) of blastocysts, the first epithelium established in mammalian development, (1) plays signaling, supportive, and patterning functions during preimplantation development, (2) ensures embryo implantation into the uterine wall, and (3) gives rise to extraembryonic tissues essential for embryo patterning and growth after implantation. We show that mouse TE, itself permissive to lentiviral (LV) infection, represents a robust nonpermeable physical barrier to the virus particles, thereby shielding the cells of the inner cell mass from viral infection. This LV feature will allow modulations of gene expression in a lineage-specific manner, thus having significant applications in mouse functional genetics. |
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Authors:
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Anna Malashicheva; Benoît Kanzler; Elena Tolkunova; Didier Trono; Alexey Tomilin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genesis (New York, N.Y. : 2000) Volume: 45 ISSN: 1526-954X ISO Abbreviation: Genesis Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-12 Completed Date: 2007-09-19 Revised Date: 2008-04-04 |
Medline Journal Info:
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Nlm Unique ID: 100931242 Medline TA: Genesis Country: United States |
Other Details:
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Languages: eng Pagination: 456-9 Citation Subset: IM |
Affiliation:
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Department of Developmental Biology, Max-Planck Institute for Immunobiology, Freiburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Lineage* Female Gene Transfer Techniques* Genes, Reporter Genetic Vectors* Lentivirus* Male Mice Mice, Inbred C57BL |
| Comments/Corrections | |
Erratum In:
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Genesis. 2007 Dec;45(12):793 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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