Document Detail

Lentigo maligna: melanoma in situ on chronically sun-damaged skin.
MedLine Citation:
PMID:  21732771     Owner:  NLM     Status:  In-Data-Review    
Abstract Context.-Cutaneous primary invasive malignant melanoma often is classified by its histologic appearance. Major recognized histologic subtypes of melanoma include superficial spreading, lentigo maligna melanoma, nodular, and acral lentiginous. More recently, it has been shown that most primary invasive melanomas harbor nonrandom genetic or biochemical aberrations that correlate with anatomic site or with the amount of cutaneous exposure to sunlight. It also is generally accepted that most primary invasive melanomas are preceded by an intraepidermal atypical melanocytic proliferation that lacks invasive capability (melanoma in situ). Objective.-To focus on lentigo maligna, the preinvasive/in situ form of melanoma located on chronically sun-damaged skin. Data Sources.-Review of the literature and the authors' personal experiences. Conclusions.-A better understanding of the earliest stage of melanoma progression, including the contribution of chronic exposure to ultraviolet radiation, may lead to improved classification schemes that direct more effective targeted or personalized therapies for patients.
Jon A Reed; Christopher R Shea
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  135     ISSN:  1543-2165     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-07-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  838-41     Citation Subset:  AIM; IM    
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