| Length-tension relationships of small arteries, veins, and lymphatics from the rat mesenteric microcirculation. | |
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MedLine Citation:
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PMID: 17172274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The passive and active length-tension relationships of isolated rat mesenteric lymphatics ( approximately 150 microm ID), and adjacent small arteries ( approximately 240 microm) and veins ( approximately 275 microm) were compared under isometric conditions using a wire myograph. About 60% of the lymphatic vessels developed spontaneous contractions in physiological saline solution at nominal preload. To maximally activate smooth muscle, 145 mM K(+) + 5 x 10(-5) M norepinephrine was used for arteries, and 145 mM K(+) + 1 x 10(-6) M substance P was used for lymphatics and veins. In response, arteries exhibited monotonic force development to a plateau level, whereas lymphatics and veins showed biphasic force development, consisting of a transient force peak followed by partial relaxation to a plateau over approximately 5 min. The passive and the active length-tension curves were similar in shape among all three vessels. However, the maximal active tension of arteries (3.4 +/- 0.42 mN/mm) was significantly greater than peak active tension (0.59 +/- 0.04 mN/mm) or plateau tension (0.20 +/- 0.04 mN/mm) in small veins and greater than peak active tension (0.34 +/- 0.02 mN/mm) or plateau tension (0.21 +/- 0.02 mN/mm) in lymphatics. Maximal active medial wall stress was similar between lymphatics and veins but was approximately fivefold higher in small arteries. For lymphatics, the pressure calculated from the optimal preload was significantly higher than that found previously in isobaric studies of isolated lymphatics, suggesting the capacity to operate at higher than normal pressures for increased responsiveness. Our results represent the first mechanical comparisons of arterial, venous, and lymphatic vessels in the same vasculature. |
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Authors:
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Rong-Zhen Zhang; Anatoliy A Gashev; David C Zawieja; Michael J Davis |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2006-12-15 |
Journal Detail:
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Title: American journal of physiology. Heart and circulatory physiology Volume: 292 ISSN: 0363-6135 ISO Abbreviation: Am. J. Physiol. Heart Circ. Physiol. Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-04-10 Completed Date: 2007-05-23 Revised Date: 2011-02-21 |
Medline Journal Info:
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Nlm Unique ID: 100901228 Medline TA: Am J Physiol Heart Circ Physiol Country: United States |
Other Details:
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Languages: eng Pagination: H1943-52 Citation Subset: IM |
Affiliation:
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1Department of Pathology and Laboratory Medicine, The University of Texas Medical School at Houston, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Isometric Contraction / physiology* Lymphatic System / physiology* Male Mesenteric Arteries / physiology* Mesenteric Veins / physiology* Microcirculation / physiology Muscle, Smooth, Vascular / physiology* Pressure Rats Rats, Sprague-Dawley Stress, Mechanical Vasoconstriction / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL-072989/HL/NHLBI NIH HHS; HL-075199/HL/NHLBI NIH HHS; R01 HL075199-04/HL/NHLBI NIH HHS; RR-017353/RR/NCRR NIH HHS |
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