| Length-dependent pathogenic effects of nickel nanowires in the lungs and the peritoneal cavity. | |
| | |
MedLine Citation:
|
PMID: 22023084 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Abstract The use of fibre-shaped nanomaterials in commercial applications has met with concern that they could cause health effects similar to those seen with pathogenic fibres such as certain forms of asbestos. Of the attributes which form the fibre pathogenicity paradigm, fibre length is thought to be a critical factor in determining fibre toxicity. We have previously shown that carbon nanotubes display such length-dependent pathogenicity but it remains unclear if other forms of fibrous nanomaterials conform to the fibre pathogenicity paradigm. As such, our aim is to determine the generality of this hypothesis by asking whether a radically different form of fibrous nanomaterial, nickel nanowires, show length-dependent pathogenicity. Our results indicate that nickel nanowires synthesised to be predominantly long (>20 μm) show the ability to elicit strong inflammation in the mouse peritoneal model in a dose-dependent manner; inflammation or fibrosis was not seen with the short (<5 μm) nanowires. This length-dependent response was also seen after lung aspiration and within a macrophage in vitro model adding further weight to the contention that fibre length is an important driver of hazard potential. This may have important implications when considering the hazard posed by fibrous nanomaterials and their regulation in workplaces. |
| | |
Authors:
|
Craig A Poland; Fiona Byrne; Wan-Seob Cho; Adriele Prina-Mello; Fiona A Murphy; Gemma Louise Davies; J M D Coey; Yurii Gounko; Rodger Duffin; Yuri Volkov; Ken Donaldson |
Related Documents
:
|
22622154 - Localization of nav 1.7 in the normal and injured rodent olfactory system indicates a c... 22510824 - Production of tnf-α, nitric oxide and hydrogen peroxide by macrophages from mice with ... 11228404 - Immunity against cancer: lessons learned from melanoma. 16914564 - Improving antitumor immune responses by circumventing immunoregulatory cells and mechan... 19378024 - Toll-like receptors and rheumatoid arthritis. 15050954 - Role of transforming growth factor beta in breast carcinogenesis. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-10-24 |
Journal Detail:
|
Title: Nanotoxicology Volume: - ISSN: 1743-5404 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
|
Created Date: 2011-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101233132 Medline TA: Nanotoxicology Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Safenano, Institute of Occupational Medicine , Research Avenue North, Riccarton, Edinburgh , UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sfp-type 4'-phosphopantetheinyl transferase is required for lysine synthesis, tolerance to oxidative...
Next Document: Phosphorescent Sensor for Biological Mobile Zinc.