Document Detail


Lenalidomide: immunomodulatory, antiangiogenic, and clinical activity in solid tumors.
MedLine Citation:
PMID:  17288877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lenalidomide is a novel analog of thalidomide with both immunomodulatory and antiangiogenic properties that are more potent than those same properties in the parent compound. Work in several antiangiogenic model systems has provided early evidence of potential mechanisms of its clinical activity. Recent US Food and Drug Administration approval of lenalidomide for patients with deletion 5q myelodysplastic syndromes and advanced multiple myeloma has provided impetus for further evaluation of this agent in solid tumors.
Authors:
Robert Dreicer
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current oncology reports     Volume:  9     ISSN:  1523-3790     ISO Abbreviation:  Curr Oncol Rep     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-02-09     Completed Date:  2007-04-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888967     Medline TA:  Curr Oncol Rep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Affiliation:
Department of Solid Tumor Oncology, Taussig Cancer Center, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA. Dreicer@ccf.org
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MeSH Terms
Descriptor/Qualifier:
Angiogenesis Inhibitors / therapeutic use*
Humans
Immunologic Factors / therapeutic use*
Neoplasms / drug therapy*
Thalidomide / analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Immunologic Factors; 191732-72-6/lenalidomide; 50-35-1/Thalidomide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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