| Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver. | |
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MedLine Citation:
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PMID: 12551749 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the preventive effect of the lemon flavonoid, eriocitrin (eriodictyol 7-O-rutinoside), on oxidative stress during acute exercise in vivo, levels of N( epsilon )- (hexanoyl)lysine, HEL; o,o-dityrosine, DT; and nitrotyrosine, NT, as oxidative stress markers, were determined by ELISA in livers of trained rats in addition to thiobarbituric acid-reactive substance (TBARS). Eriocitrin administration prior to exercise significantly suppressed the increases in TBARS caused by lipid peroxidation during acute exercise. The contents of HEL, DT, and NT in rat liver increased dramatically by exercise without eriocitrin administration. However, these increases were significantly suppressed by eriocitrin administration before exercise. Moreover, in this study, to clarify whether eriocitrin influences glutathione metabolite system that is considered to be important for a defense against the damage by oxidative stress, the levels of glutathione in rat liver were determined during exercise. The level of reduced glutathione after exercise was maintained by administration of eriocitrin. The increase in the concentration of oxidized glutathione caused by exercise was significantly suppressed by eriocitrin. This result suggested that eriocitrin might play an important role in the control of the change in glutathione redox status in rat liver during exercise. These findings showed that eriocitrin was effective in the prevention of oxidative damages caused by acute exercise-induced oxidative stress. |
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Authors:
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Ken-ichiro Minato; Yoshiaki Miyake; Syuichi Fukumoto; Kanefumi Yamamoto; Yoji Kato; Yoshiharu Shimomura; Toshihiko Osawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Life sciences Volume: 72 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2003 Feb |
Date Detail:
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Created Date: 2003-01-28 Completed Date: 2003-02-26 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 1609-16 Citation Subset: IM |
Affiliation:
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Miyagi Agricultural College, 982-0215, Sendai, Japan. minato@miyanou.ac.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Enzyme-Linked Immunosorbent Assay Flavanones* Glutathione / metabolism* Hesperidin / analogs & derivatives*, pharmacology* Hexanols / metabolism Lipid Peroxidation / drug effects* Liver / drug effects*, metabolism Lysine / chemistry Male Oxidative Stress / drug effects* Physical Conditioning, Animal* Rats Rats, Wistar Thiobarbituric Acid Reactive Substances / metabolism Tyrosine / analogs & derivatives*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Flavanones; 0/Hexanols; 0/Thiobarbituric Acid Reactive Substances; 0/eriocitrin; 3604-79-3/3-nitrotyrosine; 520-26-3/Hesperidin; 55520-40-6/Tyrosine; 56-87-1/Lysine; 70-18-8/Glutathione; 980-21-2/dityrosine |
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