Document Detail

Lemon flavonoid, eriocitrin, suppresses exercise-induced oxidative damage in rat liver.
MedLine Citation:
PMID:  12551749     Owner:  NLM     Status:  MEDLINE    
To examine the preventive effect of the lemon flavonoid, eriocitrin (eriodictyol 7-O-rutinoside), on oxidative stress during acute exercise in vivo, levels of N( epsilon )- (hexanoyl)lysine, HEL; o,o-dityrosine, DT; and nitrotyrosine, NT, as oxidative stress markers, were determined by ELISA in livers of trained rats in addition to thiobarbituric acid-reactive substance (TBARS). Eriocitrin administration prior to exercise significantly suppressed the increases in TBARS caused by lipid peroxidation during acute exercise. The contents of HEL, DT, and NT in rat liver increased dramatically by exercise without eriocitrin administration. However, these increases were significantly suppressed by eriocitrin administration before exercise. Moreover, in this study, to clarify whether eriocitrin influences glutathione metabolite system that is considered to be important for a defense against the damage by oxidative stress, the levels of glutathione in rat liver were determined during exercise. The level of reduced glutathione after exercise was maintained by administration of eriocitrin. The increase in the concentration of oxidized glutathione caused by exercise was significantly suppressed by eriocitrin. This result suggested that eriocitrin might play an important role in the control of the change in glutathione redox status in rat liver during exercise. These findings showed that eriocitrin was effective in the prevention of oxidative damages caused by acute exercise-induced oxidative stress.
Ken-ichiro Minato; Yoshiaki Miyake; Syuichi Fukumoto; Kanefumi Yamamoto; Yoji Kato; Yoshiharu Shimomura; Toshihiko Osawa
Related Documents :
18166119 - Improvement of glutathione and total antioxidant status with yoga.
10734519 - Megaloblastic marrow in macrocytic anaemias at kenyatta national and m p shah hospitals...
22622819 - Influence of self-efficacy on compliance to workplace exercise.
4314119 - Metabolism of vitamin d. a new cholecalciferol metabolite, involving loss of hydrogen a...
20975299 - Serum vaspin concentrations are decreased after exercise-induced oxidative stress.
22382039 - Intermittent maximal exercise improves attentional performance only in physically activ...
10066689 - Heart rate during exercise with leg vascular occlusion in spinal cord-injured humans.
16112839 - Freewheel running selectively prevents mouse cd4+ intestinal lymphocyte death produced ...
12834519 - Effects of exercise training added to ongoing hormone replacement therapy on bone miner...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  72     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2003 Feb 
Date Detail:
Created Date:  2003-01-28     Completed Date:  2003-02-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1609-16     Citation Subset:  IM    
Miyagi Agricultural College, 982-0215, Sendai, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Enzyme-Linked Immunosorbent Assay
Glutathione / metabolism*
Hesperidin / analogs & derivatives*,  pharmacology*
Hexanols / metabolism
Lipid Peroxidation / drug effects*
Liver / drug effects*,  metabolism
Lysine / chemistry
Oxidative Stress / drug effects*
Physical Conditioning, Animal*
Rats, Wistar
Thiobarbituric Acid Reactive Substances / metabolism
Tyrosine / analogs & derivatives*,  metabolism
Reg. No./Substance:
0/Flavanones; 0/Hexanols; 0/Thiobarbituric Acid Reactive Substances; 0/eriocitrin; 3604-79-3/3-nitrotyrosine; 520-26-3/Hesperidin; 55520-40-6/Tyrosine; 56-87-1/Lysine; 70-18-8/Glutathione; 980-21-2/dityrosine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involve...
Next Document:  Induction of nitric oxide synthase expression by Withania somnifera in macrophages.