| Leishmania donovani-induced expression of signal regulatory protein alpha on Kupffer cells enhances hepatic invariant NKT-cell activation. | |
| | |
MedLine Citation:
|
PMID: 19877019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Signal regulatory protein alpha (SIRPalpha) and its cognate ligand CD47 have been documented to have a broad range of cellular functions in development and immunity. Here, we investigated the role of SIRPalpha-CD47 signalling in invariant NKT (iNKT) cell responses. We found that CD47 was required for the optimal production of IFN-gamma from splenic iNKT cells following exposure to the alphaGalCer analogue PBS-57 and in vivo infection of mice with Leishmania donovani. Surprisingly, although SIRPalpha was undetectable in the liver of uninfected mice, the hepatic iNKT-cell response to infection was also impaired in CD47-/- mice. However, we found that SIRPalpha was rapidly induced on Kupffer cells following L. donovani infection, via a mechanism involving G-protein-coupled receptors. Thus, we describe a novel amplification pathway affecting cytokine production by hepatic iNKT cells, which may facilitate the breakdown of hepatic tolerance after infection. |
| | |
Authors:
|
Lynette Beattie; Mattias Svensson; Alison Bune; Najmeeyah Brown; Asher Maroof; Soombul Zubairi; Katharine R Smith; Paul M Kaye |
Related Documents
:
|
1937829 - Gamma interferon-activated human macrophages and toxoplasma gondii, chlamydia psittaci,... 6357669 - Cell biology of host-parasite membrane interactions in leishmaniasis. 11179319 - Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation... 16842269 - Immunology of canine leishmaniasis. 20500089 - Arabinosylated lipoarabinomannan-mediated protection in visceral leishmaniasis through ... 16778309 - Pathophysiology of visceral leishmaniasis - some recent concepts. 15265879 - Termination of antigen-specific immunity by cd95 ligand (fas ligand) and il-10. 14627139 - Protective immune response to experimental infection with sarcocystis neurona in 57bl/6... 15520809 - Molecular mechanisms of caspase regulation during apoptosis. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of immunology Volume: 40 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-01-04 Completed Date: 2010-01-19 Revised Date: 2010-09-28 |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 117-23 Citation Subset: IM |
Affiliation:
|
Centre for Immunology and Infection, Hull York Medical School and Department of Biology, University of York, York, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens, CD47 / genetics, immunology Immune Tolerance Kupffer Cells / immunology* Leishmania donovani / immunology* Leishmaniasis, Visceral / immunology* Liver / immunology* Lymphocyte Activation* Mice Mice, Knockout Natural Killer T-Cells / immunology* Receptors, Immunologic / immunology* |
| Grant Support | |
ID/Acronym/Agency:
|
//Medical Research Council; //Wellcome Trust |
| Chemical | |
Reg. No./Substance:
|
0/Antigens, CD47; 0/Ptpns1 protein, mouse; 0/Receptors, Immunologic |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Expression of apoptosis-related genes in an ethiopian cohort study correlates with tuberculosis clin...
Next Document: IL-33 broadens its repertoire to affect dendritic cells.