| Leishmania Parasites Act as a Trojan Horse that Paralyzes the Translation System of Host Macrophages. | |
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MedLine Citation:
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PMID: 21501824 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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GP63 is an abundant GPI-anchored surface metalloprotease of Leishmania. Jaramillo et al. (2011) show that GP63 manipulates the translation system of host macrophages by cleaving mTOR, which leads to 4E-BP1 dephosphorylation. This study pioneers the observation that Leishmania parasites metabolically paralyze their host cells using an elegant translation shutoff mechanism. |
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Authors:
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Michal Shapira; Alexandra Zinoviev |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cell host & microbe Volume: 9 ISSN: 1934-6069 ISO Abbreviation: Cell Host Microbe Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-19 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101302316 Medline TA: Cell Host Microbe Country: United States |
Other Details:
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Languages: eng Pagination: 257-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Life Sciences, Ben Gurion University of the Negev, POB 653, Beer Sheva 84105, Israel. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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