| Leiomyosarcoma with osteoclast-like giant cells of the uterus: a case report and literature review. | |
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MedLine Citation:
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PMID: 20462098 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The presence of osteoclast-like giant cells (OGC) has been reported as a rare and distinct feature in uterine leiomyosarcoma. To present knowledge, 11 cases have been described in the English literature. The authors report an additional example in a 35-year-old woman who presented with a pelvic mass. Pulmonary metastasis was detected by the preoperative CT scan. The hysterectomy specimen revealed a 11.5 cm intramural mass with hemorrhagic and necrotic center The histologic examination revealed pleomorphic sarcoma with OGC. The neoplastic cells were immunoreative for smooth muscle actin and desmin. Minor intermixing component of conventional leiomyosarcoma and leiomyoma were identified at the periphery of the malignant component. The patient died of disease after 16 months of diagnosis. To our knowledge, this is the youngest case of uterine leiomyosarcoma with OGC. Leiomyosarcoma with OGC has an aggressive clinical course. The tumor may occur in young patient and may arise from pre-existing leiomyoma. |
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Authors:
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Kornkanok Sukpan; Surapan Khunamornpong; Prapaporn Suprasert; Sumalee Siriaunkgul |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of the Medical Association of Thailand = Chotmaihet thangphaet Volume: 93 ISSN: 0125-2208 ISO Abbreviation: J Med Assoc Thai Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-05-13 Completed Date: 2010-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7507216 Medline TA: J Med Assoc Thai Country: Thailand |
Other Details:
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Languages: eng Pagination: 510-5 Citation Subset: IM |
Affiliation:
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Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. kosukpan@mail.med.cmu.ac.th |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Giant Cells / pathology Humans Leiomyosarcoma / etiology, pathology*, therapy Osteoclasts Uterine Neoplasms / etiology, pathology*, therapy |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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