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Leiomyosarcoma arising in the pancreatic duct: a case report and review of the current literature.
MedLine Citation:
PMID:  20589089     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Context. Leiomyosarcomas are rare malignant smooth muscle tumors that may arise in any organ or tissue that contains smooth muscle, commonly within the gastrointestinal tract. They are most often found in the stomach, large and small intestines, and retroperitoneum. Primary pancreatic leiomyosarcoma is extremely rare, and to the best of our knowledge only 30 cases have been reported in the world literature since 1951. Our case represents the first to have a clear origin from the main pancreatic duct. Case Report. This case was diagnosed in a large, tertiary care center in Tampa, Florida. Pertinent information was obtained from chart review and interdepartmental collaboration. A mass in the tail of the pancreas was identified with large pleomorphic and spindle-shaped cells. Immunohistochemistry for vimentin, smooth muscle actin, and desmin was positive. All remaining immunohistochemical markers performed were negative. The tumor clearly originated from the pancreatic duct wall, filled and expanded the duct lumen, and was covered with a layer of benign biliary epithelium. Conclusion. Leiomyosarcoma of the pancreas is an extremely rare malignancy with few reported cases in the literature. The prognosis is poor, and treatment consists of alleviating symptoms and pain management. To our knowledge, this represents the first reported case demonstrating clear origin of a leiomyosarcoma from the pancreatic duct.
Authors:
Nicole D Riddle; Brian C Quigley; Irwin Browarsky; Marilyn M Bui
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Publication Detail:
Type:  Journal Article     Date:  2010-06-09
Journal Detail:
Title:  Case reports in medicine     Volume:  2010     ISSN:  1687-9635     ISO Abbreviation:  Case Rep Med     Publication Date:  2010  
Date Detail:
Created Date:  2010-06-30     Completed Date:  2011-07-14     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101512910     Medline TA:  Case Rep Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  252364     Citation Subset:  -    
Affiliation:
Department of Pathology and Cell Biology, University of South Florida College of Medicine, 12901 Bruce B. Downs Blvd, MDC 11, Tampa, FL 33612, USA.
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